0000000000421341
AUTHOR
M Pasta
Apoptosis rate in human germinal cells: quality assay.
Apoptosis is a process that eliminates superfluous or genetically compromised cells. Cell death is one of the most important aspects of organization of the developing, as alteration in timing, level, or pattern of cell death can lead to developmental anomalies. In our studies, we investigated apoptosis in follicular somatic and germ cells of patients with infertility problems. We found that cell death occur in human germinal vesicle, in some mature oocytes and in the oocytes that failed fertilization after ICSI (Intracytoplasmic Sperm Injection), this failure was strictly correlated with apoptosis. Still, after the Italian law number 40 of 2004, it was not available oocytes to research, and…
Apoptosis rate in human spermatozoa: a sperm quality assay.
Several studies have demonstrated the relationship between gonadotrophine serum levels and the apoptosis rate in germinal cells (Bosco et al 2005). In human, lower FSH serum levels are associated with reduced Sperm Standard Parameters in term of concentration, motility and morphology and higher sperm DNA fragmentation. Hypogonadotrope hypogonadism is a clinical condition associated with male infertility, characterized by low serum levels of gonadotrophins. In this pilot study we investigated the spermatozoa quality of 11 patients with development of hypogonadotrope hypogonadism urdergoing in vitro fertilization programs. Recombinant-FSH administered to improve the sperm parameters, apoptosi…