0000000000421596

AUTHOR

Angela Maffongelli

showing 2 related works from this author

A Misunderstood intestinal perforation believed acute pancreatitis: A case report

2015

Acute pancreatitis represents one, possible but rare, of the several complications of laparoscopic cholecystectomy. In the case reported, a 31-year-old female patient complained of abdominal pain after laparoscopic cholecystectomy. The clinical picture, the high values of serum amylase, lipase and white blood cell count and the subsequent abdominal computed tomography (CT) led to diagnose an acute biliary pancreatitis. This was pharmacologically treated, but the patient worsened in a few days. A contrastenhanced CT showed the presence of free air and effusion into the peritoneal cavity. The patient was submitted to another intervention, which revealed a 1-cm jejunal perforation. The injured…

Settore MED/18 - Chirurgia GeneraleCholecystectomy Intestinal perforation Pancreatitis
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Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility.

2021

The blue-green algae Aphanizomenon flos aquae (AFA), rich in beneficial nutrients, exerts various beneficial effects, acting in different organs including the gut. Klamin® is an AFA extract particularly rich in β-PEA, a trace-amine considered a neuromodulator in the central nervous system. To date, it is not clear if β-PEA exerts a role in the enteric nervous system. The aims of the present study were to investigate the effects induced by Klamin® on the human distal colon mechanical activity, to analyze the mechanism of action, and to verify a β-PEA involvement. The organ bath technique, RT-PCR, and immunohistochemistry (IHC) were used. Klamin® reduced, in a concentration-dependent manner, …

MaleColonmotility discomfortMethysergideGene ExpressionPharmacologyArticle-PEAContractilityTAAR1medicineSerotonin receptor antagonistAphanizomenonHumansTX341-641Myenteric plexusAgedhuman colon contractilityAged 80 and overBiological ProductsAFA extractNutrition and DieteticsDose-Response Relationship DrugChemistryNutrition. Foods and food supplyParasympatholyticsEPPTBMuscle SmoothKlamin®Middle AgedKlamin<sup>®</sup>ImmunohistochemistryMechanism of actionDietary SupplementsEnteric nervous systemFemalePeristalsismedicine.symptomBiomarkersβ-PEAFood Sciencemedicine.drugMuscle ContractionNutrients
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