0000000000425250

AUTHOR

Yuki Hirota

showing 2 related works from this author

Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum

2006

Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middl…

Doublecortin Domain ProteinsTime FactorsPopulationGreen Fluorescent ProteinsSubventricular zoneFluorescent Antibody TechniqueCell CountNerve Tissue ProteinsStriatumBiologyAnimals Genetically ModifiedMiceNeuroblastCell MovementNeuroblast migrationLateral VentriclesmedicineAnimalseducationNeuronseducation.field_of_studyMice Inbred ICRGeneral NeuroscienceStem CellsNeurogenesisNeuropeptidesCell DifferentiationInfarction Middle Cerebral ArteryArticlesCorpus StriatumOlfactory bulbStrokeDisease Models Animalmedicine.anatomical_structurenervous systemGanglion mother cellNeuroscienceMicrotubule-Associated Proteins
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Cellular Composition and Organization of the Subventricular Zone and Rostral Migratory Stream in the Adult and Neonatal Common Marmoset Brain

2011

The adult subventricular zone (SVZ) of the lateral ventricle contains neural stem cells. In rodents, these cells generate neuroblasts that migrate as chains toward the olfactory bulb along the rostral migratory stream (RMS). The neural-stem-cell niche at the ventricular wall is conserved in various animal species, including primates. However, it is unclear how the SVZ and RMS organization in nonhuman primates relates to that of rodents and humans. Here we studied the SVZ and RMS of the adult and neonatal common marmoset (Callithrix jacchus), a New World primate used widely in neuroscience, by electron microscopy, and immunohistochemical detection of cell-type-specific markers. The marmoset …

animal structuresRostral migratory streamNeurogenesisanimal diseasesSubventricular zoneArticlecommon marmosetNeural Stem CellsNeuroblastrostral migratory streamCell MovementLateral Ventriclesbiology.animalmedicineAnimalsHumansStem Cell NicheCell ProliferationbiologyGeneral NeuroscienceNeurogenesisBrainMarmosetsubventricular zoneCallithrixbiology.organism_classificationImmunohistochemistryMagnetic Resonance ImagingCallithrixNeural stem cellOlfactory bulbMicroscopy Electronmedicine.anatomical_structureAnimals Newbornnervous systemNeuroscience
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