0000000000425368
AUTHOR
Ahmed A.m. Sarhan
A novel synthetic approach to pyran-2,4-dione scaffold production : microwave-assisted dimerization, cyclization, and expeditious regioselective conversion into β-enamino-pyran-2,4-diones
Here, we report a novel, green, simple, low-cost, and rapid methodology for the high-yield production of pyran-2,4-dione scaffolds under microwave irradiation. Regio- and stereoselective conversions of β-diketone systems into β-enaminones were achieved using 18 primary amines and four amino acid esters. Microwave-assisted further cyclization of 3-(β-substitutedvinyl)-6-phenyl-pyran-2,4-dione into 3-benzoyl-4,7-diphenyl-2H,5H-pyrano[4,3-b]pyran-2,5-dione via reaction with ethyl benzoyl acetate. peerReviewed
CCDC 2034810: Experimental Crystal Structure Determination
Related Article: Ahmed A.M. Sarhan, Matti Haukka, Assem Barakat, Ahmed T.A. Boraei|2020|Tetrahedron Lett.|61|152660|doi:10.1016/j.tetlet.2020.152660