0000000000426662
AUTHOR
Alain Paris
Differential effect of hypophysectomy and growth hormone treatment on hepatic glucuronosyltransferases in male rats: Evidence for an action at a pretranslational level for isoforms glucuronidating bilirubin
International audience; The influence of growth hormone (GH) on 4-nitrophenol, bilirubin, testosterone, androsterone and estrone glucuronidation activities was studied in fully activated male rat hepatic microsomes. Sham-operated and hypophysectomized animals were injected with two different dosages of GH, mimicking either the male or female GH secretion pattern. Half the animals received thyroxine and cortisol in concentrations chosen to compensate for the lack of thyroid hormones and glucocorticoids in hypophysectomized rats. GH induced a decrease in several glucuronidation activities: bilirubin glucuronidation in both sham-operated and cortisol/ thyroxine-treated hypophysectomized rats i…
Systems biology of piglet maturity with focus on muscle metabolism
In recent decades, there has been improvement of sow prolificacy and body composition but the genetic progress has been accompanied by a substantial increase in piglet mortality before weaning. The most critical period is the first 48 hours after birth. The maturity of piglets, defined as the state of full development for survival at birth, is an important determinant of early mortality. The objective of our project is to take advantage of current knowledge about two pig breeds, Large White piglets with increased mortality and Meishan piglets being more robust at birth. Maturity of several tissues and metabolite profiles of various fluids were analyzed on the fetuses (LW, MS and reciprocal …