0000000000427668
AUTHOR
Marina Bianchi
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyeli…
Aspirin After Oral Anticoagulants for Prevention of Recurrence in Patients with Unprovoked Venous Thromboembolism. the Warfasa STUDY
Abstract Abstract 543 Background A recurrence occurs in 15–20% of patients with unprovoked venous thromboembolism (VTE) in the two years after the withdrawal of oral anticoagulant treatment. Extending anticoagulant treatment is effective but associated with increased bleeding risk. We assessed the efficacy and safety of aspirin for the prevention of VTE recurrence after a conventional course of oral anticoagulation. Methods Warfasa was an investigator-initiated double-blind randomized placebo-controlled event-driven study. Patients with a first-ever unprovoked VTE who had completed 6–12 months of oral anticoagulant treatment were randomized to receive aspirin, 100 mg daily, or placebo for a…
La heterodoxia en la poesía visual española del siglo XXI
Resumen: Toda vanguardia esconde un malestar y una rebeldia contra la realidad que aflige al individuo y que se vuelve objeto de critica en las obras. En este sentido, tras aclarar a que nos referimos cuando hablamos de poesia visual, analizaremos algunas obras que han aparecido por primera vez en 2014, interpretandolas como reaccion contra la perdida de valores de la sociedad postmoderna. La finalidad sera demostrar que la poesia visual espanola del siglo XXI no ha renunciado a su heterodoxia, puesto que elige justamente este universo donde todo es rapido, fluido, superficial, complejo e inasible para seguir denunciando desde su interior la incomunicacion y la alienacion a la que nos han l…