0000000000428550

AUTHOR

Mattia Maroso

showing 2 related works from this author

Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus

2018

Abstract Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic niche, where a multitude of extracellular signaling molecules converges to regulate NSC proliferation as well as fate and functional integration. However, the underlying mechanisms how NSCs react to extrinsic signals and convert them to intracellular responses still remains elusive. NSCs contain a functional endocannabinoid system, including the cannabinoid type-1 receptor (CB1). To decipher whether CB1 regulates adult neurogenesis directly or indirectly in vivo, we performed NSC-specific conditional inactivation of CB1 by using triple-transgenic mice. Here, we show that lack of CB1 in NSCs is su…

Male0301 basic medicineCell signalingCannabinoid receptorNeurogenesisCognitive NeuroscienceLong-Term PotentiationMice Transgenicmouse hippocampus ; neural stem cells ; neurogenesis-dependent behavior ; CB1 ; adult neurogenesisHippocampal formationBiologyHippocampus03 medical and health sciencesCellular and Molecular Neurosciencemouse hippocampus0302 clinical medicineNeural Stem CellsReceptor Cannabinoid CB1Animalsreproductive and urinary physiologySpatial MemoryBehavior AnimalNeurogenesisLong-term potentiationOriginal ArticlesCB1Endocannabinoid systemneurogenesis-dependent behaviorNeural stem cellCell biologyadult neurogenesisMice Inbred C57BL030104 developmental biologynervous systemlipids (amino acids peptides and proteins)biological phenomena cell phenomena and immunityStem cell030217 neurology & neurosurgeryCerebral Cortex
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Cannabinoid Control of Learning and Memory through HCN Channels

2016

The mechanisms underlying the effects of cannabinoids on cognitive processes are not understood. Here we show that cannabinoid type-1 receptors (CB1Rs) control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the h-current (Ih), a key regulator of dendritic excitability. The CB1R-HCN pathway, involving c-Jun-N-terminal kinases (JNKs), nitric oxide synthase, and intracellular cGMP, exerts a tonic enhancement of Ih selectively in pyramidal cells located in the superficial portion of the CA1 pyramidal cell layer, whereas it is absent from deep-layer cells. Activation of the CB1R-HCN pathway impairs d…

0301 basic medicineMAP Kinase Kinase 4medicine.medical_treatmentMorpholinesNeuroscience(all)RegulatorMice TransgenicBiologyNaphthalenesHippocampusBiophysical PhenomenaArticleMembrane Potentials03 medical and health sciencesMice0302 clinical medicineReceptor Cannabinoid CB1medicineHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAnimalsEnzyme InhibitorsReceptorCyclic GMPSpatial MemoryMembrane potentialNeuronsGeneral NeuroscienceLong-term potentiationDendritesSynaptic PotentialsCalcium Channel BlockersBenzoxazines030104 developmental biologyMutationExcitatory postsynaptic potentialCannabinoidSignal transductionNitric Oxide SynthaseNeuroscience030217 neurology & neurosurgeryIntracellularSignal TransductionNeuron
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