0000000000433555

AUTHOR

G. Guli

showing 2 related works from this author

Diorganotin(IV) dipeptide complexes with potential antitumour activity

1993

A series of complexes of the dimethylltin(IV) moiety with dipeptides has been synthesized. The dipeptides are L-alanyl-L-histidine (H2AlaHis), L-methionyl-L-methionine (H2MetMet), L-glycyl-L-histidine (H2GlyHis) and L-histidyl-L-glycine (H2HisGly). The complexes have been characterized by IR and 119Sn Mossbauer spectroscopy in the solid state and by 1H NMR in CD3OD and D2O solutions. They consist of monomeric entities, with the tin atom arranged in a pentacoordinated trigonal bipyramidal structure. The dipeptides are coordinated via the amino group, deprotonated peptide nitrogen and carboxylate group. Neither imidazole in histidine-containing dipetides, nor the thioether group in MetMet, is…

chemistry.chemical_classificationDipeptideChemistryStereochemistryPeptideGeneral ChemistryNuclear magnetic resonance spectroscopyInorganic Chemistrychemistry.chemical_compoundTrigonal bipyramidal molecular geometryThioetherMoietyImidazoleCarboxylateApplied Organometallic Chemistry
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Complexes of tryptophan dipeptides with the R2Sn(IV)2+ ion (R=Me, Ph): Spectroscopic studies, solution properties and structural implications

1995

Tryptophan dipeptides such as L-tryptophyl-L-alanine (H 2 TrpAla), L-tryptophyl-L-tyrosine (H 2 TrpTyr), L-tryptophyl-L-tryptophan (H 2 TrpTrp), along with L-histidyl-L-tyrosine (H 2 HisTyr), were reacted with R 2 SnO (R=Me, Ph) yielding the corresponding complexes. The complexes have been characterized by IR and 119 Sn Mossbauer spectroscopy in the solid state and by 1 H and 13 C NMR in CD 3 OD solutions. Monomeric species were detected, with the tin atom arranged in a pentacoordinated trigonal-bipyramidal structure. The dipeptides are coordinated via the terminal amino group, deprotonated peptide nitrogen and terminal carboxylate group. No side-chain appears to be involved in bonding. Det…

chemistry.chemical_classificationDipeptideChemistryStereochemistryTryptophanPeptideGeneral ChemistryNuclear magnetic resonance spectroscopyCarbon-13 NMRInorganic ChemistryCrystallographychemistry.chemical_compoundDeprotonationCarboxylateConformational isomerismApplied Organometallic Chemistry
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