0000000000433661

AUTHOR

M. José Martínez-sebastián

showing 2 related works from this author

Gene arrangement phylogeny of the E element in Drosophila species of the Obscura group

1993

Drosophila pseudoobscuraGene mappingbiologyPhylogeneticsEvolutionary biologyDrosophilidaeChromosomeZoologyDrosophila (subgenus)biology.organism_classificationGeneEcology Evolution Behavior and SystematicsDrosophila subobscuraJournal of Evolutionary Biology
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Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia

2013

Friedreich's ataxia (FRDA), the most common inherited ataxia, is a neurodegenerative disease caused by a reduction in the levels of the mitochondrial protein frataxin, the function of which remains a controversial matter. Several therapeutic approaches are being developed to increase frataxin expression and reduce the intramitochondrial iron aggregates and oxidative damage found in this disease. In this study, we tested separately the response of a Drosophila RNAi model of FRDA ( Llorens et al., 2007) to treatment with the iron chelator deferiprone (DFP) and the antioxidant idebenone (IDE), which are both in clinical trials. The FRDA flies have a shortened life span and impaired motor coord…

AtaxiaPyridonesUbiquinoneIronLife spanHyperoxiaBiologyPharmacologyMitochondrionmedicine.disease_causeAconitaseAntioxidantsAconitasechemistry.chemical_compoundIron-Binding ProteinsGeneticsmedicineAnimalsIdebenoneDeferiproneAconitate HydrataseHyperoxiaFrataxinClimbing capabilityGeneral MedicineMitochondriaDisease Models AnimalOxidative StressPhenotypechemistryFriedreich AtaxiaOxidative stressMutationFrataxinbiology.proteinDrosophilamedicine.symptomDeferiproneOxidative stressmedicine.drugGene
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