0000000000433739

AUTHOR

Alessandro Maugeri

0000-0002-8670-3123

showing 2 related works from this author

Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand

2019

Abstract Three heterobimetallic platinum (II)/ruthenium (II) and platinum (II)/rhodium (III) complexes, A: Pt{S–S2C2(NR)2H}{μ-S2C2(NR)2}-[Ru (p-cymene)Cl], R = isoamyl; B: Pt{S–S2C2(NR)2H}{μ-S2C2(NR)2}[Rh (phpy)2], R = isoamyl; C: [Pt{S–S2C2(NR)2H}{μ-S2C2(NR)2}-[Rh(C5Me5)Cl]], R = benzyl, were prepared from mononuclear complexes 1 and 2, 1: [Pt (H-isoamyl2DTO)2]; 2: [Pt (H-benzyl2DTO)2], DTO = dithiooxamide, by reaction of 1 or 2 with the corresponding chlorido-bridged dimers, [Rh(C5Me5)Cl (μ-Cl)]2, [Ru (p-cymene)Cl (μ-Cl)]2 or [Rh (phpy)2 (μ-Cl)]2, and then evaluated as anticancer agents for the inhibition of the three proteolytic activities of human 20S proteasome, one of the main target …

chemistry.chemical_classification010405 organic chemistryChemistryOrganic Chemistrychemistry.chemical_element010402 general chemistrymedicine.disease01 natural sciencesBiochemistryMedicinal chemistry0104 chemical sciencesRhodiumRutheniumAnticancer; Dithiooxamide; Heterobimetallic; Platinum complexes; Rhodium; RutheniumInorganic Chemistrychemistry.chemical_compoundEnzymeDithiooxamideApoptosisNeuroblastomaMaterials ChemistrymedicinePhysical and Theoretical ChemistryPlatinumCytotoxicityJournal of Organometallic Chemistry
researchProduct

Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies

2017

Background: During the last decades, a huge body of evidence has been accumulated suggesting that Citrus fruits and their juices might have a role in preventing many diseases including cancer. Objective: To summarize the numerous evidences on the potential of Citrus juices and their extracts as anticancer agents. Data sources: A systematic review of articles written in English using MEDLINE (1946-present), EMBASE (1974-present) and Web of Sciences (1970-present) was performed independently by two reviewers. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis,…

0301 basic medicineproliferationCitrus aurantifoliaUremic toxinsMEDLINECITRUS JUICEIndoxyl sulfate03 medical and health sciences0302 clinical medicineNeuroinflammationsystematic reviewCitrus paradisiChronic kidney diseaseBotanycancerMedicinePharmacology (medical)NeurodegenerationSystematic reviehumansPharmacologyTraditional medicineIndoxyl sulfate Neuroinflammation Oxidative stress Neurodegeneration Uremic toxins Chronic kidney disease Alternative medicine Cancer Citrus juice Humans In vitro In vivo Proliferation Systematic revie Pharmacology Pharmacology (medical)alternative medicinebusiness.industryData synthesislcsh:RM1-950food and beveragesin vitroin vivolcsh:Therapeutics. Pharmacology030104 developmental biologySystematic reviewSearch termsOxidative stress030220 oncology & carcinogenesisCitrus juicebusinessCitrus × sinensisFrontiers in Pharmacology
researchProduct