0000000000433788
AUTHOR
Patrizia Tosi
Differences among young adults, adults and elderly chronic myeloid leukemia patients
Abstract BACKGROUND: The incidence of chronic myeloid leukemia (CML) increases with age, but it is unclear how the characteristics of the disease vary with age. In children, where CML is very rare, it presents with more aggressive features, including huge splenomegaly, higher cell count and higher blast cell percentage. PATIENTS AND METHODS: To investigate if after childhood the disease maintains or loses these characteristics of aggressiveness, we analyzed 2784 adult patients, at least 18 years old, registered by GIMEMA CML WP over a 40-year period. RESULTS: Young adults (YAs: 18-29 years old) significantly differed from adults (30-59 years old) and elderly patients (at least 60 years old)…
Microtremor Measurements in the City of Palermo, Italy: Analysis of the Correlation between Local Geology and Damage
Abstract This study presents the results of 90 seismic ambient noise measurements in Palermo, the main city of Sicily (Italy). The dataset has been processed using the horizontal-to-vertical spectral ratio (HVNSR) technique and interpreted in terms of local geology, which is characterized by the presence of alluvial sediments of two riverbeds masked by urbanization since the seventeenth century. HVNSRs show significant variations in the study area: when the transition stiff to soft is crossed, a typical spectral peak appears in the HVNSRs, mostly in the frequency band 1–2 Hz, and exceeding a factor of 3 in amplitude. Using available information on subsurface geological structure, we compute…
Lenalidomide Maintenance After Autologous Stem-Cell Transplantation in Newly Diagnosed Multiple Myeloma: A Meta-Analysis
Purpose Lenalidomide maintenance therapy after autologous stem-cell transplantation (ASCT) demonstrated prolonged progression-free survival (PFS) versus placebo or observation in several randomized controlled trials (RCTs) of patients with newly diagnosed multiple myeloma (NDMM). All studies had PFS as the primary end point, and none were powered for overall survival (OS) as a primary end point. Thus, a meta-analysis was conducted to better understand the impact of lenalidomide maintenance in this setting. Patients and Methods The meta-analysis was conducted using primary-source patient-level data and documentation from three RCTs (Cancer and Leukemia Group B 100104, Gruppo Italiano Malatti…