New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens
The synthesis and the in vitro antibacterial activity of novel linezolid-like oxadiazoles are reported. Replacement of the linezolid morpholine C-ring with 1,2,4-oxadiazole results in an antibacterial activity against Staphylococcus aureus both methicillin-susceptible and methicillin-resistant comparable or even superior to that of linezolid. While acetamidomethyl or thioacetoamidomethyl moieties in the C(5) side-chain are required, fluorination of the phenyl B ring exhibits a slight effect on an antibacterial activity but its presence seems to reduce the compounds cytotoxicity. Molecular modeling performed using two different approaches - FLAP and Amber software - shows that in the binding…
Moving from North to North: how are the students’ university flows?
AbstractStudent mobility has been much commented upon and much studied. Student mobility has social, economic, and political consequences. This form of mobility is relevant, in Italy, in terms of south-north flows, while the mobility of northern students toward the South and Centre of Italy is negligible. To the best of our knowledge, a proper focus on the dynamics among northern regions has not yet been carried out. This study focuses on the interregional mobility of northern first-year students. To this end, we use a longitudinal dataset with students’ individual histories from 2008 to 2017, obtained from the cohort-based datasets collected using the Italian Ministry of University’s admin…