0000000000437469

AUTHOR

Gary M. Clifford

showing 3 related works from this author

Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men

2018

Background Identifying determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive MSM would allow better targeted screening. Methods APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged ≥35 in six clinics across France. At baseline, participants underwent high resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. hHSIL diagnosis was established by histopathological review panel consensus, and determinants assessed by logistic regression. Results Baseline hHSIL prevalence was 10.4% and did not differ significantly by…

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryHuman immunodeficiency virus (HIV)medicine.diseasemedicine.disease_causeLogistic regressionlcsh:Infectious and parasitic diseasesLesionInfectious DiseasesVirologyInternal medicineCytologyBiopsymedicinelcsh:RC109-216medicine.symptomProspective cohort studybusinessAscusImmunodeficiencyPapillomavirus Research
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Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus–Positive Men Who Have Sex with Men

2018

A correction has been published:The Journal of Infectious Diseases, Volume 218, Issue 8, 15 October 2018, Page 1350, https://doi.org/10.1093/infdis/jiy315; International audience; Background:We assessed prevalence and risk factors for anal human papillomavirus (HPV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), who are at high-risk of HPV-related anal cancer.Methods:APACHES is a multicentric, prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35 years. At baseline, participants underwent anal swabs for HPV and cytology, plus high-resolution anoscopy. High-risk HPV (HR-HPV) was tested by Cobas4800, with genotyping of HR-HPV positiv…

medicine.medical_specialtymen who have sex with menMen who have sex with men03 medical and health sciences0302 clinical medicineInternal medicinemedicineImmunology and AllergyAnal cancer030212 general & internal medicineanal canalProspective cohort studyhuman papillomavirusGenotypinghigh-resolution anoscopy[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologymedicine.diagnostic_testhuman immunodeficiency virusbusiness.industryHPV infectionAnoscopyvirus diseasesOdds ratio16. Peace & justicemedicine.diseaseConfidence intervalfemale genital diseases and pregnancy complications3. Good healthInfectious Diseases030220 oncology & carcinogenesisbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Determinants of high-grade anal intraepithelial lesions in HIV-positive MSM.

2018

Objective - To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive men who have sex with men (MSM), a population at high-risk of HPV-related anal cancer. Design - APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged at least 35 years in six centres across France. Methods - At baseline, participants underwent high-resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. hHSIL diagnosis was established by histopathological review panel consensus, and determinants assessed by logistic regression. Results - B…

AdultMalemedicine.medical_specialtyBiopsyImmunologyPopulationHIV InfectionsMen who have sex with men03 medical and health sciences0302 clinical medicineCytologyInternal medicineBiopsymedicinePrevalenceImmunology and AllergyAnal cancerHumans030212 general & internal medicineProspective StudiesHomosexuality MaleProspective cohort studyeducationAgededucation.field_of_studyHuman papillomavirus 16medicine.diagnostic_testbusiness.industryPapillomavirus InfectionsAnoscopyMiddle Agedmedicine.diseaseAnus Neoplasms3. Good healthInfectious Diseases030220 oncology & carcinogenesisFemaleFranceSquamous Intraepithelial Lesions of the CervixbusinessAscusAIDS (London, England)
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