0000000000437477

AUTHOR

Isabelle Heard

showing 4 related works from this author

Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men

2018

Background Identifying determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive MSM would allow better targeted screening. Methods APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged ≥35 in six clinics across France. At baseline, participants underwent high resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. hHSIL diagnosis was established by histopathological review panel consensus, and determinants assessed by logistic regression. Results Baseline hHSIL prevalence was 10.4% and did not differ significantly by…

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryHuman immunodeficiency virus (HIV)medicine.diseasemedicine.disease_causeLogistic regressionlcsh:Infectious and parasitic diseasesLesionInfectious DiseasesVirologyInternal medicineCytologyBiopsymedicinelcsh:RC109-216medicine.symptomProspective cohort studybusinessAscusImmunodeficiencyPapillomavirus Research
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Head and neck squamous cell carcinoma in people living with HIV in France.

2018

Abstract Objectives Head and neck squamous cell carcinoma (HNSCC), mainly due to smoking, is one of the leading causes of cancer deaths. However, an increasing number of tumors – especially oropharyngeal cancer – are reported in non-smokers in association with the human papillomavirus (HPV). As HIV-infected individuals are particularly at risk of HPV-related disease, we aimed to describe the burden of HNSCC in this population. Methods Retrospective chart review of patients from HIV clinics diagnosed with HNSCC between 2004 and 2014. Case patients were defined using the International Classification of Disease for Oncology (3rd edition). Age at HIV diagnosis and time from HIV diagnosis to HNS…

LarynxOncologyMalemedicine.medical_specialtyPopulationHuman immunodeficiency virus (HIV)HIV InfectionsDiseasemedicine.disease_causeCauses of cancer03 medical and health sciences0302 clinical medicineInternal medicineotorhinolaryngologic diseasesCarcinomamedicineHumans030212 general & internal medicineeducationLaryngeal NeoplasmsComputingMilieux_MISCELLANEOUSRetrospective Studieseducation.field_of_studyHypopharyngeal Neoplasmsbusiness.industrySquamous Cell Carcinoma of Head and Neckvirus diseasesCancerMiddle Agedmedicine.diseaseHead and neck squamous-cell carcinoma[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology3. Good healthstomatognathic diseasesInfectious Diseasesmedicine.anatomical_structure030220 oncology & carcinogenesis[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology[SDV.IMM]Life Sciences [q-bio]/ImmunologyFemaleMouth NeoplasmsFrancebusinessMedecine et maladies infectieuses
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Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus–Positive Men Who Have Sex with Men

2018

A correction has been published:The Journal of Infectious Diseases, Volume 218, Issue 8, 15 October 2018, Page 1350, https://doi.org/10.1093/infdis/jiy315; International audience; Background:We assessed prevalence and risk factors for anal human papillomavirus (HPV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), who are at high-risk of HPV-related anal cancer.Methods:APACHES is a multicentric, prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35 years. At baseline, participants underwent anal swabs for HPV and cytology, plus high-resolution anoscopy. High-risk HPV (HR-HPV) was tested by Cobas4800, with genotyping of HR-HPV positiv…

medicine.medical_specialtymen who have sex with menMen who have sex with men03 medical and health sciences0302 clinical medicineInternal medicinemedicineImmunology and AllergyAnal cancer030212 general & internal medicineanal canalProspective cohort studyhuman papillomavirusGenotypinghigh-resolution anoscopy[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologymedicine.diagnostic_testhuman immunodeficiency virusbusiness.industryHPV infectionAnoscopyvirus diseasesOdds ratio16. Peace & justicemedicine.diseaseConfidence intervalfemale genital diseases and pregnancy complications3. Good healthInfectious Diseases030220 oncology & carcinogenesisbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Determinants of high-grade anal intraepithelial lesions in HIV-positive MSM.

2018

Objective - To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive men who have sex with men (MSM), a population at high-risk of HPV-related anal cancer. Design - APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged at least 35 years in six centres across France. Methods - At baseline, participants underwent high-resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. hHSIL diagnosis was established by histopathological review panel consensus, and determinants assessed by logistic regression. Results - B…

AdultMalemedicine.medical_specialtyBiopsyImmunologyPopulationHIV InfectionsMen who have sex with men03 medical and health sciences0302 clinical medicineCytologyInternal medicineBiopsymedicinePrevalenceImmunology and AllergyAnal cancerHumans030212 general & internal medicineProspective StudiesHomosexuality MaleProspective cohort studyeducationAgededucation.field_of_studyHuman papillomavirus 16medicine.diagnostic_testbusiness.industryPapillomavirus InfectionsAnoscopyMiddle Agedmedicine.diseaseAnus Neoplasms3. Good healthInfectious Diseases030220 oncology & carcinogenesisFemaleFranceSquamous Intraepithelial Lesions of the CervixbusinessAscusAIDS (London, England)
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