0000000000437481

AUTHOR

Isabelle Etienney

showing 4 related works from this author

Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men

2018

Background Identifying determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive MSM would allow better targeted screening. Methods APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged ≥35 in six clinics across France. At baseline, participants underwent high resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. hHSIL diagnosis was established by histopathological review panel consensus, and determinants assessed by logistic regression. Results Baseline hHSIL prevalence was 10.4% and did not differ significantly by…

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryHuman immunodeficiency virus (HIV)medicine.diseasemedicine.disease_causeLogistic regressionlcsh:Infectious and parasitic diseasesLesionInfectious DiseasesVirologyInternal medicineCytologyBiopsymedicinelcsh:RC109-216medicine.symptomProspective cohort studybusinessAscusImmunodeficiencyPapillomavirus Research
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What is the optimal treatment for T1N0 anal squamous cell carcinoma? Analysis of current practices in the prospective French FFCD ANABASE cohort

2021

International audience; Introduction: for localized T1N0 squamous cell carcinoma of the anus (SCCA) standard radiotherapy (RT) may result in overtreatment and alternative strategies are debated. Methods: T1N0M0 SCCA treated between 2015 and 2020 by local excision (LE) or RT were analyzed from the French prospective FFCD ANABASE cohort. Treatment strategies, recurrence-free and colostomy-free survivals (RFS, CFS) and prognostic factors were reported. Results: among 1135 SCCA patients, 99 T1N0M0 were treated by LE(n = 17,17.2%), or RT ( n = 82,82.8%) including RT alone ( n = 65,79.2%) or chemo-RT ( n = 17, 20.7%). Median follow-up was 27.2 months [0.03 and ndash;54.44]. Median tumor size were…

Malemedicine.medical_specialtyLocal excisionLocal excisionmedicine.medical_treatmentAnal Canal[SDV.CAN]Life Sciences [q-bio]/CancerGastroenterologyDisease-Free Survival03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumans030212 general & internal medicineAgedRetrospective StudiesAged 80 and overUnivariate analysisHepatologyRadiotherapybusiness.industryOptimal treatmentGastroenterologyAnal Squamous Cell CarcinomaChemoradiotherapyMiddle AgedAnusAnus Neoplasms3. Good healthRadiation therapymedicine.anatomical_structureAnal canal carcinoma030220 oncology & carcinogenesisCohortCarcinoma Squamous CellFemaleFrancebusinessChemoradiotherapy
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Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus–Positive Men Who Have Sex with Men

2018

A correction has been published:The Journal of Infectious Diseases, Volume 218, Issue 8, 15 October 2018, Page 1350, https://doi.org/10.1093/infdis/jiy315; International audience; Background:We assessed prevalence and risk factors for anal human papillomavirus (HPV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), who are at high-risk of HPV-related anal cancer.Methods:APACHES is a multicentric, prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35 years. At baseline, participants underwent anal swabs for HPV and cytology, plus high-resolution anoscopy. High-risk HPV (HR-HPV) was tested by Cobas4800, with genotyping of HR-HPV positiv…

medicine.medical_specialtymen who have sex with menMen who have sex with men03 medical and health sciences0302 clinical medicineInternal medicinemedicineImmunology and AllergyAnal cancer030212 general & internal medicineanal canalProspective cohort studyhuman papillomavirusGenotypinghigh-resolution anoscopy[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologymedicine.diagnostic_testhuman immunodeficiency virusbusiness.industryHPV infectionAnoscopyvirus diseasesOdds ratio16. Peace & justicemedicine.diseaseConfidence intervalfemale genital diseases and pregnancy complications3. Good healthInfectious Diseases030220 oncology & carcinogenesisbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Determinants of high-grade anal intraepithelial lesions in HIV-positive MSM.

2018

Objective - To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive men who have sex with men (MSM), a population at high-risk of HPV-related anal cancer. Design - APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged at least 35 years in six centres across France. Methods - At baseline, participants underwent high-resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. hHSIL diagnosis was established by histopathological review panel consensus, and determinants assessed by logistic regression. Results - B…

AdultMalemedicine.medical_specialtyBiopsyImmunologyPopulationHIV InfectionsMen who have sex with men03 medical and health sciences0302 clinical medicineCytologyInternal medicineBiopsymedicinePrevalenceImmunology and AllergyAnal cancerHumans030212 general & internal medicineProspective StudiesHomosexuality MaleProspective cohort studyeducationAgededucation.field_of_studyHuman papillomavirus 16medicine.diagnostic_testbusiness.industryPapillomavirus InfectionsAnoscopyMiddle Agedmedicine.diseaseAnus Neoplasms3. Good healthInfectious Diseases030220 oncology & carcinogenesisFemaleFranceSquamous Intraepithelial Lesions of the CervixbusinessAscusAIDS (London, England)
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