0000000000441689

AUTHOR

Ronald Borra

showing 6 related works from this author

Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men - …

2014

Background Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle and pose extremely high costs to the healthcare system. In this study, we aim to explore whether individualized aerobic exercise (AEx) and low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition and other post-interventional effects. Methods/design A 6-month randomized intervention with 6-month follow-up is conducted from January 2013 to December 2015. The target sample size for intervention is 200 postmenopausal women and middle-aged men aged 50–65 year-old with pre-diabetes and NAFLD. The qualified…

MaleHealth BehaviorPATHOGENESISPhysiologyGut floralaw.inventionImpaired glucose toleranceDiet Carbohydrate-RestrictedStudy ProtocolRandomized controlled trialNon-alcoholic Fatty Liver DiseaselawSurveys and QuestionnairesEPIDEMIOLOGYGlucose metabolismbiologyMicrobiotaFatty liverMiddle AgedPostmenopauseLiverResearch DesignMetabonomicsOBESITYBody CompositionFemaleLIFE-STYLELiver fat contentHumanmedicine.medical_specialtyGut microbiotaCarbohydrate metabolismCHINAPrediabetic StateIMPAIRED GLUCOSE-TOLERANCEDiabetes mellitusInternal medicineDietary CarbohydratesmedicineHumansAerobic exerciseExerciseLife StyleAgedbusiness.industryPublic Health Environmental and Occupational HealthDIABETES-MELLITUSFeeding BehaviorADULTSmedicine.diseasebiology.organism_classificationObesityGastrointestinal TractClinical settingMICEEndocrinologyLipid metabolismDietary SupplementsbusinessBMC Public Health
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Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity

2011

Background & Aims: Ectopic fat in muscle and liver is linked to obesity and type 2 diabetes. Recently, pancreatic lipid accumulation has also been associated with beta-cell dysfunction and reduced insulin production, leading to the development of type 2 diabetes. Physical exercise training has been shown to attenuate beta-cell dysfunction in patients, but little is known about its effects on pancreatic and hepatic fat accumulation. In this study, we validated in-vivo proton magnetic resonance spectroscopy ((1)H MRS) in pancreatic fat measurement with biochemical measurements in a pig model. Thereafter, the effects of increased physical activity on the amounts of pancreatic and liver fat…

MaleSwinemedicine.medical_treatmentSus scrofaAdipose tissueMonozygotic twinACID UPTAKEType 2 diabetesFatty Acids NonesterifiedFat Measurement0302 clinical medicineFatty AcidsHEPATIC INSULIN-RESISTANCEMagnetic Resonance Imagingmedicine.anatomical_structureADIPOSE-TISSUEAdipose TissueLiverModels AnimalSwine Miniature030211 gastroenterology & hepatologyPancreasMonozygotic twinsAdultmedicine.medical_specialty030209 endocrinology & metabolismDEPENDENT DIABETES-MELLITUSMotor ActivityBiologyta3111HISPANIC ADOLESCENTSYoung Adult03 medical and health sciencesInsulin resistanceBETA-CELL FUNCTIONInternal medicineMagnetic resonance spectroscopymedicineMAGNETIC-RESONANCE SPECTROSCOPYAnimalsHumansADIPONECTIN CONCENTRATIONSPancreasPLASMA ADIPONECTINHepatologyPhysical activityInsulinTRIGLYCERIDE CONTENTTwins MonozygoticLipid Metabolismmedicine.diseaseObesityEndocrinologyInsulin ResistanceJournal of Hepatology
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Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease

2015

Article

MaleMagnetic Resonance Spectroscopymedicine.medical_treatmentBiopsyAdipose tissuelcsh:MedicineFats0302 clinical medicineNon-alcoholic Fatty Liver DiseaseMetabolitesTerveystiede - Health care scienceSkeletal musclesAmino Acidslcsh:ScienceNon-U.S. Gov'tchemistry.chemical_classification0303 health sciencesMultidisciplinaryResearch Support Non-U.S. Gov'tFatty liverFatty AcidsrasvamaksaMiddle Aged3. Good healthAmino acidmedicine.anatomical_structureAdipose TissueLiverFemaleResearch Articlemedicine.medical_specialtyAdipose tissue030209 endocrinology & metabolismamino acid metabolismBiologyResearch Support03 medical and health sciencesInsulin resistanceInternal medicineFatty livermedicineJournal ArticleHumansObesityFatty acids030304 developmental biologyfatty liverCatabolismInsulinta1184lcsh:RFatty acidSkeletal muscleta3121medicine.diseaseEndocrinologychemistrylcsh:QGene expression
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Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial.

2017

AbstractThe study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50–65-year fulfilled the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx n = 29), diet (Diet n = 28), exercise plus diet (AED n = 29), or no-intervention (NI n = 29) groups. Progressive supervised AEx training (60–75% VO2max intensity) was gi…

Lifestyle modificationMaleLIFE-STYLE INTERVENTIONSlcsh:MedicineruokavaliotGastroenterologyImpaired glucose tolerance0302 clinical medicineWeight lossNon-alcoholic Fatty Liver DiseaseMedicinelcsh:Science10. No inequalityIN-VIVOAdipositySPECTROSCOPYMultidisciplinaryINSULIN SENSITIVITYdietary fibreFatty liverrasvamaksaMiddle Aged3. Good healthIntention to Treat AnalysisTreatment OutcomeLiverdietsDisease Progression030211 gastroenterology & hepatologyFemaleaerobic trainingmedicine.symptommedicine.medical_specialtyTYPE-2 DIABETES-MELLITUSWEIGHT-LOSS030209 endocrinology & metabolismArticlePrediabetic State03 medical and health sciencesIMPAIRED GLUCOSE-TOLERANCEInsulin resistanceInternal medicineAerobic exerciseHumansHEPATIC STEATOSISExercise physiologyExerciseMETAANALYSISfatty liverGlycated HemoglobinIntention-to-treat analysisHepatologybusiness.industrylcsh:Raerobinen harjoittelumedicine.diseaseImpaired fasting glucoseDietravintokuitulcsh:QNORDIC WALKINGInsulin ResistancebusinessBiomarkersScientific reports
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Effects of aerobic exercise and diet intervention on glycaemic control and liver fat content in men and women aged 50–65 years with prediabetes and n…

2016

Abstract Background Prediabetes and non-alcoholic fatty liver disease precede development of type 2 diabetes; however, appropriate lifestyle interventions might help to prevent such progression. We aimed to test whether aerobic exercise training and a high-fibre diet can reduce hepatic fat content and increase insulin sensitivity in individuals with prediabetes and non-alcoholic fatty liver disease. Methods We did a randomised controlled trial in seven clinics in Yangpu district, Shanghai, China. We recruited individuals aged 50–65 years with impaired fasting glucose (5·6–6·9 mmol/L) or impaired glucose tolerance (2 h glucose 7·8–11·0 mmol/L) and diagnosed non-alcoholic fatty liver disease.…

medicine.medical_specialtyEndocrinology Diabetes and MetabolismPopulationType 2 diabeteslaw.inventionImpaired glucose tolerance03 medical and health sciences0302 clinical medicineEndocrinologyRandomized controlled triallawInternal medicineInternal MedicinemedicineAerobic exercise030212 general & internal medicinePrediabeteseducationeducation.field_of_studybusiness.industryFatty livermedicine.diseaseImpaired fasting glucosePhysical therapybusiness030217 neurology & neurosurgeryThe Lancet Diabetes & Endocrinology
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Gut-adipose tissue axis in hepatic fat accumulation in humans

2014

Recent evidence suggests that in animals gut microbiota composition (GMC) affects the onset and progression of hepatic fat accumulation. The aim of this study was to investigate in humans whether subjects with high hepatic fat content (HHFC) differ in their GMC from those with low hepatic fat content (LHFC), and whether these differences are associated with body composition, biomarkers and abdominal adipose tissue inflammation.Hepatic fat content (HFC) was measured using proton magnetic resonance spectroscopy ((1)H MRS). Fecal GMC was profiled by 16S rRNA fluorescence in situ hybridization and flow cytometry. Adipose tissue gene expression was analyzed using Affymetrix microarrays and quant…

AdultMalemedicine.medical_specialtyPathologyeducationGene ExpressionAdipose tissueFaecalibacterium prausnitziiInflammationGut florata3111Insulin resistanceNon-alcoholic Fatty Liver DiseaseInternal medicineGene expressionmedicineHumansTriglyceridesInflammationHepatologybiologymedicine.diagnostic_testMicrobiotata1183ta1182ta3141Middle Agedta3121biology.organism_classificationmedicine.diseaseCross-Sectional StudiesEndocrinologyReal-time polymerase chain reactionAdipose TissueLiverBody CompositionFemaleInsulin Resistancemedicine.symptomDigestive SystemFluorescence in situ hybridizationJournal of Hepatology
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