0000000000443380

AUTHOR

M. G. Siragusa

showing 2 related works from this author

Transbuccal tablets of carbamazepine: formulation, release and absorption pattern.

2006

Tranbsuccal drug administration is an attractive method, as it has several advantages especially with respect to peroral delivery. Here we report: i) the aptitude of carbamazepine (CBZ) to penetrate porcine buccal mucosa and reconstituted human oral (RHO) epithelium; ii) three different tablet formulations for transbuccal administration; iii) the drug release rate from tablets. CBZ permeation through the buccal mucosa was investigated by using two different bi-compartmental open models: Franz cells for porcine buccal mucosa and Transwell diffusion cells system for RHO epithelium. Results, expressed as drug flux (Js) and permeability coefficients (Kp), indicated that CBZ well penetrates the …

CarbamazepineCheekSolubilitySwineSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoChemistry PharmaceuticalSettore MED/50 - Scienze Tecniche Mediche ApplicateMouth MucosaAdministration BuccalAnimalsbuccal permeation modelling transbuccal drug delivery carbamazepine polyacrylic acid microspheres tablets matrices tabletsAbsorptionTablets
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Current status in buccal drug delivery

2008

This article overviews the progress made in buccal drug delivery research during the last five years and reports a new high-tech approach to achieve controlled delivery.

Drug permeationSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoBuccal drug deliverySettore MED/50 - Scienze Tecniche Mediche ApplicateIntelliDrug deviceBuccal drug delivery; Drug permeation; Promoting buccal absorption; IntelliDrug devicePromoting buccal absorption
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