Bone-Targeted Cisplatin-Complexed Poly(γ-benzyl-L-glutamate)-Poly(glutamic acid) Block Polymer Nanoparticles: An Electrochemical Approach

The voltammetric response of different osteotropic multifunctional nanoparticles based on cisplatin-complexed poly(γ-benzyl-L-glutamate)–poly(glutamic acid) block polymer (CDDP-PBLG-b-PGlu) copolymer, with or without poly(γ-benzyl-L-glutamate)–poly(ethylene glycol) block polymer (PBLG-b-PEG), and having bone-targeting properties is studied at biologically relevant pH. Significant differences in the cisplatin-centered voltammetric signals allow monitoring of the association of cisplatin to nanoparticles as well as release kinetics from them, in agreement with atomic absorption spectroscopy data. Electrochemical studies reveal that the cisplatin association is significant only if the proporti…