0000000000445325

AUTHOR

Angelo Peluso

showing 3 related works from this author

Cardiac and hepatic iron and ejection fraction in thalassemia major: Multicentre prospective comparison of combined Deferiprone and Deferoxamine ther…

2013

Background: Due to the limited data available in literature, the aim of this multi-centre study was to prospectively compare in thalassemia major (TM) patients the efficacy of combined deferiprone (DFP) and deferoxamine (DFO) regimen versus either DFP and DFO in monotherapy by cardiovascular magnetic resonance (CMR) over a follow up of 18 months. Methods: Among the first 1135 TM patients in the MIOT (Myocardial Iron Overload in Thalassemia) network, we evaluated those who had received either combined regimen (DFO + DFP, N=51) or DFP (N=39) and DFO (N=74) monotherapies between the two CMR scans. Iron overload was measured by T2* multiecho technique. Biventricular function parameters were qua…

MaleLiver Iron ConcentrationTime FactorsThalassemiaVentricular Function Leftchemistry.chemical_compoundMedicineDeferiproneProspective StudiesMedicine(all)Ejection fractionRadiological and Ultrasound TechnologyBeta thalassemiaDeferoxamineTreatment OutcomeItalyLiverCardiologyThalassemiaDrug Therapy CombinationFemaleCardiology and Cardiovascular MedicineDeferiproneCardiomyopathiesmedicine.drugAdultmedicine.medical_specialtyCombination therapyPyridonesChelation therapyMagnetic Resonance Imaging CineDeferoxamineIron Chelating AgentsYoung AdultPredictive Value of TestsInternal medicineHumansRadiology Nuclear Medicine and imagingChelation therapyAnalysis of VarianceChi-Square Distributionbusiness.industryResearchMyocardiumbeta-ThalassemiaStroke Volumemedicine.diseaseSurgerychemistryVentricular Function RightCardiovascular magnetic resonancebusinessJournal of Cardiovascular Magnetic Resonance
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Myocardial fibrosis by delayed enhancement cardiovascular magnetic resonance and HCV infection in thalassemia major patients

2010

ss Open Acce Oral presentation Myocardial fibrosis by delayed enhancement cardiovascular magnetic resonance and HCV infection in thalassemia major patients Alessia Pepe1, Antonella Meloni1, Zelia Borsellino2, Maria Chiara Dell'Amico1, Vincenzo Positano1, Caterina Borgna-Pignatti3, Aurelio Maggio4, Gennaro Restaino5, Francesco Gagliardotto2, Paolo Cianciulli6, Luciano Prossomariti7, Aldo Filosa7, Michele Centra8, Domenico D'Ascola9, Antonella Quarta10, Angelo Peluso11, Antonello Pietrangelo12, Eliana Cracolici13, Massimo Lombardi*1 and Marcello Capra2

Medicine(all)lcsh:Diseases of the circulatory (Cardiovascular) systemmedicine.medical_specialtyRadiological and Ultrasound Technologymedicine.diagnostic_testbusiness.industryThalassemiaMagnetic resonance imagingDelayed enhancementmedicine.diseaselcsh:RC666-701Internal medicinemedicineCardiologyRadiology Nuclear Medicine and imagingMyocardial fibrosisCardiology and Cardiovascular MedicinebusinessAngiologyJournal of Cardiovascular Magnetic Resonance
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Improvement of heart iron with preserved patterns of iron store by CMR-guided chelation therapy

2014

[Formula: see text] multislice multiecho cardiac magnetic resonance (CMR) allows quantification of the segmental distribution of myocardial iron overload (MIO). We evaluated whether a preferential pattern MIO was preserved between two CMR scans in regularly chelated thalassaemia major (TM) patients.We evaluated prospectively 259 TM patients enrolled in the MIO in Thalassaemia (MIOT) network with a CMR follow-up (FU) study at 18 ± 3 months and significant MIO at baseline. The [Formula: see text] in the 16 segments and the global value were calculated. Four main circumferential regions (anterior, septal, inferior and lateral) were defined. We identified two groups: severe (n = 80, global [For…

AdultMalemedicine.medical_specialtyIron OverloadHeart DiseasesCardiac magnetic resonanceMagnetic Resonance Imaging CineMyocardial ironRisk AssessmentIron storeAnterior regionCohort StudiesMyocardial iron overloadInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingMultisliceProspective StudiesChelation therapyThalassaemia majorbusiness.industryPreferential patternbeta-ThalassemiaThalassaemia majorGeneral MedicineMiddle AgedChelation TherapySurgeryTreatment OutcomeCardiologyFemaleCardiology and Cardiovascular MedicinebusinessCardiac magnetic resonanceFollow-Up StudiesEuropean Heart Journal – Cardiovascular Imaging
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