0000000000447145

AUTHOR

Muhammad N. Ahmed

0000-0002-3768-873x

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Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

2021

Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to thank the Erkko Foundation and Nordforsk Nordic center of Excellency NordAqua (project number #82845) and University of Helsinki’s Doctoral Programme in Microbiology and Biotechnology funding to M.N.A. D.O.A. was supported by a postdoctoral research fellowship from the São Paulo Research Foundation (FAPESP #2018/01563-2). We thank Biocenter Kuopio for the use of their facilities for molecular modeling and MD simulations. We thank the DNA Sequenci…

Proteasesserine proteases116 Chemical sciencesproteaasiluonnontuotteet01 natural sciencesBiochemistryGenomeproteomiikkaSerine03 medical and health sciencesCell Line TumorGene clusterinhibitorsHumansIC50Genetrypsiinit030304 developmental biologyCell ProliferationinhibiittoritSerine protease0303 health sciencesBiological Productsbiologybiokemia010405 organic chemistryCell growthChemistrybioinformatiikkaGeneral MedicineArticlesseriiniproteaasi0104 chemical sciences3. Good healthsyöpäsolutBiochemistryGenes Bacterialbiology.proteinMolecular MedicineproteasessyöpätauditproteiinitTrypsin InhibitorsAzabicyclo CompoundsNodulariaAeruginosins
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