0000000000451166
AUTHOR
Denis Dossarps
Evaluation of two treatment-modalities with ranibizumab for exudative age-related macular degeneration: inject and extend vs PRN (pro-re-nata)
Evaluation of two treatment-modalities with ranibizumab for exudative age-related macular degeneration: inject and extend vs PRN (pro-re-nata). annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Inflammatory cytokines decrease viability and alter ganglioside profile in retinal pigment epithelium cells
Purpose Early stages of Age related Macular Degeneration (AMD) are characterized by dysfunction and degeneration of the retinal pigment epithelium (RPE) cells, which participate in the death of the overlying photoreceptors ultimately leading to loss of vision. Gangliosides (GG) make a wide and heterogeneous family of sialic-acid-containing glycosphingolipids, composed of a sugar chain branched on a ceramide. They are major components of cellular membranes, particularly abundant in the brain and nervous tissue, including retina. While their developmental and neuroprotective actions have been demonstrated, their precise role in retina’s function and its pathologies is still poorly understood.…
Retinopathy of prematurity screening: evaluation of a first screening
Purpose: Retinopathy of prematurity (ROP) screening concerns preterm infants born before 32 weeks of amenorrhea and/or weighting less than 1500 grams. First screening occurs usually 4 to 6 weeks after birth and always after 31 weeks of amenorrhea. The purpose of this study was to investigate the number of examinations performed before the first signs of retinopathy, in order to determine the best time for first screening.Methods: This retrospective study enrolled preterm infants born before 32 weeks of amenorrhea and/or weighting less than 1500 grams in the University Hospital of Dijon, France, between 11/15/2012 and 12/31/2013. All preterm babies benefited from a ROP screening by fundus ph…
Endophthalmitis after intravitreal injections: incidence, presentation, management, and visual outcome
Purpose To report the incidence and characteristics of endophthalmitis after intravitreal injections of anti–vascular endothelial growth factor agents or corticosteroids and to describe the clinical and bacteriologic characteristics, management, and outcome of these eyes with acute endophthalmitis in France. Design Retrospective, nationwide multicenter case series. Methods From January 2, 2008 to June 30, 2013, a total of 316 576 intravitreal injections from 25 French ophthalmic centers were included. For each center, the number of intravitreal injections was determined using billing codes and the injection protocol was recorded. A registry and hospital records were reviewed to identify pat…
Plasma gangliosides and age-related macular degeneration
Purpose Age-related macular degeneration (AMD) is a multifactorial and polygenic disease and is the main cause of vision loss in developed countries after 50 years old. Indeed, dry AMD leads to progressive retinal atrophy and exsudative AMD induces a rapid alteration of the macula through neovascularisation. Gangliosides (GG) make a wide and heterogeneous family of sialic-acid-containing glycosphingolipids, composed of a sugar chain branched on a ceramide. They are major components of cellular membranes and are particularly abundant in the brain and nervous tissue, including retina. They are also found circulating in the plasma. GG are known for their neuroprotective properties in the nervo…