showing 2 related works from this author
Social defeat in adolescent mice increases vulnerability to alcohol consumption
2014
This study employs an oral operant conditioning paradigm to evaluate the effects of repeated social defeat during adolescence on the reinforcing and motivational actions of ethanol in adult OF1 mice. Social interaction, emotional and cognitive behavioral aspects were also analyzed, and real-time polymerase chain reaction (PCR) experiments were performed to study gene expression changes in the mesocorticolimbic and hypothalamus-hypophysis-adrenal (HHA) axis. Social defeat did not alter anxiety-like behavior in the elevated plus maze or cognitive performance in the passive avoidance and Hebb-Williams tests. A social interaction test revealed depression-like symptoms and social subordination b…
SY29-3SOCIAL DEFEAT IN ADOLESCENT MICE INCREASES VULNERABILITY TO ALCOHOL CONSUMPTION
2015
Background. Stressful life situations have been widely linked to drug-seeking. Several studies in humans and animal models have demonstrated that exposure to different kinds of stress increases abuse and relapse to abuse of certain drugs such as alcohol. Methods. This study employs an oral operant conditioning paradigm to evaluate the …