0000000000451582
AUTHOR
Giuseppe Longo
Feasibility of 1 arcmin resolution gamma-ray air-Čerenkov multiple telescope experiment
Abstract In this paper we discuss the feasibility of a ground based detector exploiting the technique of Cerenkov light stereo imaging of air showers for the detection of discrete cosmic sources of γ-rays with energy threshold of 100 GeV, angular resolution (HWHM) of 1 arcmin ( 1 3 mrad), cosmic ray background rejection ≥ 99%. This experiment will make possible a deep survey of the sky with sensitivity of 1 100 of the Crab in 45 h of exposure.
The liquid-argon scintillation pulseshape in DEAP-3600
AbstractDEAP-3600 is a liquid-argon scintillation detector looking for dark matter. Scintillation events in the liquid argon (LAr) are registered by 255 photomultiplier tubes (PMTs), and pulseshape discrimination (PSD) is used to suppress electromagnetic background events. The excellent PSD performance of LAr makes it a viable target for dark matter searches, and the LAr scintillation pulseshape discussed here is the basis of PSD. The observed pulseshape is a combination of LAr scintillation physics with detector effects. We present a model for the pulseshape of electromagnetic background events in the energy region of interest for dark matter searches. The model is composed of (a) LAr scin…
Symplectic analysis of thin-walled curved box girders with torsion, distortion and shear lag warping effects
Shear lag effect and torsional and distortional warping can significantly affect the performance of thin-walled curved box girders used in modern bridge engineering. The structural behaviour of these bridges exhibits complexity due to coupled bending and torsion together with warping effects of non-uniform torsion, distortion and shear lag. A practical method of analysis, based on the symplectic approach, with the same perspective as the Higher Order Beam Theories, is presented for overcoming the difficulties of numerical approaches via the Finite Element Method. In this paper, the Hamiltonian Structural Analysis method implements the analysis of the shear lag effect together with non-unifo…
Anaplastic large cell lymphoma (CD30+/Ki-1+). Analysis of 35 cases followed at GISL centres
Between January 1988 and June 1992, 35 patients with primary anaplastic large cell lymphoma (ALCL)CD30+ were referred to one of the institutions participating in GISL (Gruppo Italiano per lo Studio dei Linformi). 16 patients were treated with ProMACE-CytaBOM, two with MACOP-B, one with CHOP and one with LSA2-L2. As of November 1990, all newly diagnosed patients were treated with MOPP/EBV/CAD hybrid. 27 (77%) cases of ALCL CD30+ and 8 (23%) cases of Hodgkin's-related (HR) lymphoma CD30+ were diagnosed. Extranodal disease was present in 22 cases (63%), and 8 patients (23%) had primary bone marrow involvement. Twenty-three complete remissions (CR) (66%), six partial remissions (PR) (17%) and s…
Feasibility, Tolerability and Efficacy of Carfilzomib in Combination with Lenalidomide and Dexamethasone in Relapsed Refractory Myeloma Patients: A Retrospective Real-Life Survey of the Sicilian Myeloma Network
Background: The ASPIRE (NCT01080391) phase 3 trial showed the efficacy of carfilzomib, lenalidomide and dexamethasone (KRd) triplet for relapse and refractory multiple myeloma (RRMM). However, little is known about safety and efficacy of KRd outside a clinical trial context. Methods: Herein we report real life results of KRd given to 130 RRMM patients from 12 Sicilian Centers. Results: Median age was 62 years
Impact of Cumulative Dose of Carfilzomib in Combination with Lenalidomide and Dexamethasone in Relapsed Refractory Myeloma Patients: A Retrospective Real Life Survey of the Sicilian Myeloma Network
Abstract Background: Triplet-based lenalidomide plus dexamethasone (Rd) combinations have become the new standard of care for early relapse and refractory multiple myeloma (RRMM). Carfilzomib is a novel selective proteasome inhibitor (PI) with high efficacy in RRMM. The ASPIRE phase 3 trial showed the superiority of carfilzomib-based triplet (KRd compared to Rd), leading to approval of K for RRMM. However, little is known about safety and efficacy of KRd outside a clinical trial context. Experimental design and aims: In 11 Sicilian Centers belonging to the Sicilian Myeloma Network, from November 2016, when KRd regimen was approved in Italy, to June 2018, 103 consecutive RRMM patients (previ…
Construction sequence analysis of long-span cable-stayed bridges
Abstract In cantilever construction of long-span cable-stayed bridges the stressing sequence of stays is fundamental for establishing the final configuration of the bridge. The structural behaviour of these bridges is usually evaluated through a forward staged construction analysis, in which the values of the prestressing forces to be applied to stays are the main unknowns. A unified procedure for determining the initial cable forces and for analyzing the entire sequence is presented here, considering the geometric nonlinearity of stays through the Dischinger equivalent elastic modulus. The target is the simultaneous determination of the initial cable forces with the simulation of the const…
Steel and composite tied-arch bridges: a conceptual approach to structural design
The behaviour of tied-arch bridges with composite decks (bowstring bridges) is overly sensitive to the different choices made by the designer in the first phases of the conceptual approach, mainly in the design of the arch and the deck. The geometry of the arch shape, the design of the arch–tie joint and the construction sequence can significantly modify the global behaviour in terms of stress state and deformed configuration. After a general discussion on the different parameters affecting the behaviour of bowstring bridges with steel–concrete composite decks, the consequences of choices made in the conceptual design phases are discussed, analysing the effects of each choice on the global…