0000000000451758

AUTHOR

Sabine Rabini

showing 2 related works from this author

Multiple mechanistic anti-inflammatory activity of STW5-II on mouse intestinal organoids

2020

Chemistrymedicine.drug_classCancer researchIntestinal organoidsmedicineAnti-inflammatoryDGVS Digital: BEST OF DGVS
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Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids

2021

Abstract Background Irritable bowel syndrome (IBS) is a functional bowel disorder, in which recurrent abdominal pain is associated with defecation or a change in bowel habits. STW 5-II is a combination of six medicinal herbs with a clinically proven efficacy in managing IBS. Aim This study aims to establish an in vitro IBS model using mouse intestinal organoids and to explore the anti-inflammatory and tight junction protective activities of the multi-herbal preparation STW 5-II. Methods Intestinal organoids were cultured in 1:1 Matrigel™ and medium domes. Inflammation and tight junction disruption were induced by a cocktail of cytokines (TNFα, IFNγ, IL-1β, IL-6) and bacterial proteins (LPS,…

Anti-Inflammatory AgentsPharmaceutical ScienceInflammationPharmacologyTight JunctionsProinflammatory cytokineIrritable Bowel SyndromeMice03 medical and health sciencesOrgan Culture Techniques0302 clinical medicineWestern blotDownregulation and upregulationDrug DiscoverymedicineOrganoidAnimalsComputer SimulationIntestinal MucosaIrritable bowel syndrome030304 developmental biologyPharmacology0303 health sciencesTight junctionmedicine.diagnostic_testPlant Extractsbusiness.industryNF-kappa Bmedicine.diseaseIntestinesOrganoidsDisease Models AnimalSTAT1 Transcription FactorGene Expression RegulationComplementary and alternative medicine030220 oncology & carcinogenesisZonula Occludens-1 ProteinMolecular MedicineTumor necrosis factor alphaInflammation Mediatorsmedicine.symptombusinessPhytomedicine
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