0000000000456513

AUTHOR

Guo-du Wang

showing 2 related works from this author

Glucagon-Like Peptide-1 Modulates Neurally-Evoked Mucosal Chloride Secretion in the Guinea Pig Ileum In Vitro

2011

medicine.medical_specialtyEndocrinologyHepatologyNeurally-Evoked Mucosal Chloride SecretionChemistryInternal medicineGastroenterologymedicineGlucagon-Like Peptide-1Chloride secretionGuinea pig ileumGlucagon-like peptide-1In vitroGastroenterology
researchProduct

Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro

2011

Glucagon-like peptide-1 (GLP-1) acts at the G protein-coupled receptor, GLP-1R, to stimulate secretion of insulin and to inhibit secretion of glucagon and gastric acid. Involvement in mucosal secretory physiology has received negligible attention. We aimed to study involvement of GLP-1 in mucosal chloride secretion in the small intestine. Ussing chamber methods, in concert with transmural electrical field stimulation (EFS), were used to study actions on neurogenic chloride secretion. ELISA was used to study GLP-1R effects on neural release of acetylcholine (ACh). Intramural localization of GLP-1R was assessed with immunohistochemistry. Application of GLP-1 to serosal or mucosal sides of fla…

MaleCytoplasmendocrine systemmedicine.medical_specialtyReceptors Vasoactive Intestinal Polypeptide Type IPhysiologyGuinea PigsScopolamineVasoactive intestinal peptideHormones and SignalingIleumIn Vitro TechniquesHexamethoniumGlucagonGlucagon-Like Peptide-1 ReceptorCholine O-AcetyltransferaseGuinea pigChloridesGlucagon-Like Peptide 1IleumPhysiology (medical)Internal medicineIntestine SmallReceptors GlucagonmedicineAnimalsNeuropeptide YSecretionIntestinal MucosaNeuronsHepatologyChemistrydigestive oral and skin physiologyElectric ConductivityGastroenterologyAcetylcholineElectric StimulationPeptide FragmentsSmall intestineElectrophysiological PhenomenaEndocrinologymedicine.anatomical_structureSomatostatinELAV ProteinsGastric acidCarbacholSomatostatinhormones hormone substitutes and hormone antagonistsVasoactive Intestinal PeptideAmerican Journal of Physiology-Gastrointestinal and Liver Physiology
researchProduct