0000000000458453

AUTHOR

Dirk H Busch

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Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients Is Associated with Protracted Cold Ischemic Time of Seropositive Donor O…

2017

Human Cytomegalovirus (CMV) can lead to primary infection or reactivation in CMV-seronegative or -seropositive kidney transplant recipients, respectively. Complications comprise severe end-organ diseases and acute or chronic transplant rejection. Risk for CMV manifestation is stratified according to the CMV-IgG-serostatus, with donor+/recipient- (D+/R-) patients carrying the highest risk for CMV-replication. However, risk factors predisposing for primary infection in CMV-seronegative recipients are still not fully elucidated. Therefore, we monitored D+/R- high-risk patients undergoing kidney transplantation in combination with antiviral prophylaxis for the incidence of CMV-viremia for a med…

Cytomegalovirus InfectionMaleViral DiseasesT-Lymphocyteslcsh:MedicineCytomegalovirusPathology and Laboratory MedicineCell-Mediated ImmunityWhite Blood CellsAnimal CellsMedicine and Health SciencesRenal TransplantationPublic and Occupational Healthlcsh:ScienceImmunity CellularT CellsCold Ischemiavirus diseasesVaccination and ImmunizationTissue DonorsInfectious DiseasesMedical MicrobiologyViral PathogensVirusesCytomegalovirus InfectionsHuman CytomegalovirusFemaleCellular TypesPathogensResearch ArticleHerpesvirusesImmune CellsImmunologySurgical and Invasive Medical ProceduresCytotoxic T cellsSerogroupMicrobiologyUrinary System ProceduresHumansViremiaMicrobial PathogensTransplantationBlood CellsProphylaxislcsh:ROrganismsImmunityBiology and Life SciencesCell BiologyOrgan TransplantationKidney Transplantationlcsh:QPreventive MedicineDNA virusesPLoS ONE
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