Interacciones entre activadores y represores en el inicio de la transcripción en Saccharomyces cerevisiae

2010

Autosomic dominant lateral temporal epilepsy (ADLTE) is a form of partial epilepsy with secondary generalized seizures, caused by mutations in LGI1. This gene was initially identified in 1998, as a tumour suppressor in multiform glioblastoma, affecting to the malignancy of these tumours. In silico analysis of the primary sequence of LGI1, revealed four paralogues of the gene, which shared a very similar domain structure and were named as LGI1, LGI2, LGI3 and LGI4. The existence of similar types of epilepsy with common features for that seen for ADLTE, suggests that some other members of this gene family could be involved in these pathologies. Moreover, the presence of four paralogues, makes…