0000000000460023

AUTHOR

Inmaculada Royo

showing 2 related works from this author

Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors

2005

The antitumoral activity of a series of acetylated bis-tetrahydrofuranic acetogenins with a threo/trans/threo/trans/erythro relative configuration was characterized by four new natural and two semisynthetic, 15,24,30-trioxygenated acetogenins that were found to inhibit mitochondrial complex I enzyme as well as growth of several tumor cell lines. Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents.

Spectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyAcetogeninsStereochemistryClinical BiochemistryPharmaceutical ScienceAntineoplastic AgentsBiochemistryChemical synthesisLactonesStructure-Activity Relationshipchemistry.chemical_compoundCell Line TumorNeoplasmsDrug DiscoveryHumansStructure–activity relationshipMolecular BiologyCell Proliferationchemistry.chemical_classificationElectron Transport Complex IMolecular StructureChemistryCell growthOrganic ChemistryBiological activityGrowth InhibitorsEnzymeBiochemistryAcetylationCell cultureAcetogeninMolecular MedicineFatty AlcoholsBioorganic & Medicinal Chemistry
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New antitumoral acetogenin ‘Guanacone type’ derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone

2007

We describe herein the isolation and semisynthesis of four acetogenin derivatives (1-4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported.

Models MolecularMagnetic Resonance SpectroscopyAcetogeninsStereochemistryLipid BilayersClinical BiochemistryMolecular ConformationRespiratory chainPharmaceutical ScienceBiochemistryChemical synthesisAnnonaElectron TransportLactoneschemistry.chemical_compoundPolyketideCell Line TumorDrug DiscoveryHumansComputer SimulationFuransMolecular BiologyPOPCBilayerOrganic ChemistryHydrogen BondingAntineoplastic Agents PhytogenicSemisynthesisMitochondrial respiratory chainchemistrySeedsAcetogeninPhosphatidylcholinesMolecular MedicineIndicators and ReagentsFatty AlcoholsBioorganic & Medicinal Chemistry
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