0000000000461710
AUTHOR
Irene Del-canto
showing 5 related works from this author
Comparative Analysis of Tagging and Feature-Tracking Cardiac MRI Techniques for the Evaluation of Cardiac Deformation
2020
[EN] Currently, there is a high prevalence of cardiovascular diseases, being the leading cause of mortality worldwide. Thus, a rapid and effective evaluation of the heart is increasingly relevant to diagnose the patient early and achieve appropriate treatment. For this reason, this study aims to compare myocardial deformation parameters such as circumferential strain (segmental, base, mid, apical and global) and global torsion values by the CMR tissue tagging reference technique in SPAMM cine images and the promising feature-tracking technique in b-SSFP cine images, in 31 healthy subjects and 35 patients diagnosed with infarct. The results obtained showed that there is a high agreement in t…
CaMKII inhibition reduces electrical activation heterogeneities caused by mechanical stretch in the myocardium
2020
Abstract Introduction Ca2+/calmodulin-dependant protein kinase II (CaMKII) activity in cardiomyocytes plays a crucial role in their contractility. Increased CaMKII signalling has been associated with mechanical stretch, often caused in the border zone of myocardial infarction. CaMKII upregulation causes a mishandling of intracellular calcium, a precursor of multiple pro-arrhythmic mechanisms, such as early afterdepolarisations. Purpose In this study, we aim to quantify the effects of KN-93 -a CaMKII inhibitor- on wave dynamics, in order to investigate its effectiveness as an anti-arrhythmic agent. Methods An isolated Langendorff model was constructed based on rabbit hearts (n=18) and poster…
PSPU-Net for Automatic Short Axis Cine MRI Segmentation of Left and Right Ventricles
2020
[EN] Characterization of the heart anatomy and function is mostly done with magnetic resonance image cine series. To achieve a correct characterization, the volume of the right and left ventricle need to be segmented, which is a timeconsuming task. We propose a new convolutional neural network architecture that combines U-net with PSP modules (PSPU-net) for the segmentation of left and right ventricle cavities and left ventricle myocardium in the diastolic frame of short-axis cine MRI images and compare its results against a classic 3D U-net architecture. We used a dataset containing 399 cases in total. The results showed higher quality results in both segmentation and final volume estimati…
Ranolazine-Mediated Attenuation of Mechanoelectric Feedback in Atrial Myocyte Monolayers.
2020
[EN] Background Mechanical stretch increases Na(+)inflow into myocytes, related to mechanisms including stretch-activated channels or Na+/H(+)exchanger activation, involving Ca(2+)increase that leads to changes in electrophysiological properties favoring arrhythmia induction. Ranolazine is an antianginal drug with confirmed beneficial effects against cardiac arrhythmias associated with the augmentation ofI(NaL)current and Ca(2+)overload. Objective This study investigates the effects of mechanical stretch on activation patterns in atrial cell monolayers and its pharmacological response to ranolazine. Methods Confluent HL-1 cells were cultured in silicone membrane plates and were stretched to…
Characterization of normal regional myocardial function by MRI cardiac tagging
2013
Purpose The aim of this study was to establish reference values for segmental myocardial strain measured by magnetic resonance (MR) cardiac tagging in order to characterize the regional function of the heart. Material and Methods We characterized the left ventricular (LV) systolic deformation in 39 subjects (26 women and 13 men, age 58.8 ± 11.6 years) whose cardiological study had not revealed any significant abnormality. The deformation was measured from MR-tagged (Siemens 1.5T MR) images using an algorithm based on sine wave modeling. Circumferential and radial peak systolic strain values along with the torsion angle and circumferential-longitudinal (CL) shear were determined in 16 LV seg…