0000000000462082

AUTHOR

Alex Bienaime

showing 2 related works from this author

Influence of a Thiolate Chemical Layer on GaAs (100) Biofunctionalization: An Original Approach Coupling Atomic Force Microscopy and Mass Spectrometr…

2013

International audience; Widely used in microelectronics and optoelectronics; Gallium Arsenide (GaAs) is a III-V crystal with several interesting properties for microsystem and biosensor applications. Among these; its piezoelectric properties and the ability to directly biofunctionalize the bare surface, offer an opportunity to combine a highly sensitive transducer with a specific bio-interface; which are the two essential parts of a biosensor. To optimize the biorecognition part; it is necessary to control protein coverage and the binding affinity of the protein layer on the GaAs surface. In this paper; we investigate the potential of a specific chemical interface composed of thiolate molec…

self-assembled thiolate monolayersMaterials scienceAnalytical chemistryproteins grafting02 engineering and technology010402 general chemistryMass spectrometrylcsh:Technology01 natural sciencesArticleGallium arsenideGaAs; self-assembled thiolate monolayers; proteins grafting; AFM; MALDI-TOF MSchemistry.chemical_compoundMonolayerMALDI-TOF MSMoleculeMicroelectronicsGeneral Materials Science[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronicslcsh:Microscopylcsh:QC120-168.85lcsh:QH201-278.5lcsh:Tbusiness.industryGaAs021001 nanoscience & nanotechnology0104 chemical sciencesMatrix-assisted laser desorption/ionizationchemistryChemical engineeringlcsh:TA1-2040Docking (molecular)lcsh:Descriptive and experimental mechanics[ SPI.NANO ] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronicslcsh:Electrical engineering. Electronics. Nuclear engineeringAFMlcsh:Engineering (General). Civil engineering (General)0210 nano-technologybusinesslcsh:TK1-9971BiosensorMaterials
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Reconstitution of a protein monolayer on thiolates functionalized gaas surface

2012

International audience; In the aim to realize an efficient resonant biosensor, gallium arsenide (GaAs) presents many advantages. In addition to its properties of transduction, GaAs is a crystal for which microfabrication processes were developed, conferring the possibility to miniaturize the device and integrate electronic circuit. Moreover, the biofunctionalization could be realized on the crystalline surface without layer deposition, constituting a real advantage to perform reusable sensor. The functionalization of GaAs surface was engaged in order to immobilize a protein monolayer on this substrate. Functionalization was done using a mixed self assembled monolayer of thiolate molecules. …

Materials scienceBioengineeringNanotechnology02 engineering and technologySubstrate (electronics)010402 general chemistry01 natural sciences[SPI.AUTO]Engineering Sciences [physics]/AutomaticGallium arsenidechemistry.chemical_compound[ SPI.AUTO ] Engineering Sciences [physics]/AutomaticMonolayerGeneral Materials ScienceElectrical and Electronic EngineeringSelf-assembled monolayer021001 nanoscience & nanotechnologyCondensed Matter Physics0104 chemical sciencesComputer Science ApplicationschemistrySurface modification0210 nano-technologyBiosensorLayer (electronics)BiotechnologyMicrofabrication
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