0000000000462805

AUTHOR

Hans-jakob Steiger

showing 3 related works from this author

Local Delivery of Nimodipine by Prolonged-Release Microparticles—Feasibility, Effectiveness and Dose-Finding in Experimental Subarachnoid Hemorrhage

2012

Background and purposeTo investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH).Methods70 male Wistar rats were categorized into three groups: 1) sham operated animals (control), 2) animals with SAH only (control) and the 3) treatment group. SAH was induced using the double hemorrhage model. The treatment group received different concentrations (20%, 30% or 40%) of nimodipine microparticles. Angiographic vasospasm was assessed 5 days later using digital subtraction angiography (DSA). Histological analysis of frozen sections was performed using H&E-staining as …

MaleVasodilator AgentsGene ExpressionPolylactic Acid-Polyglycolic Acid CopolymerVasospasm IntracranialDrug DistributionMultidisciplinarymedicine.diagnostic_testMicrofilament ProteinsQRBrainIntracranial ArteryVasospasmAnimal ModelsImmunohistochemistryHemorrhagic StrokeNeurologyAnesthesiaInjections IntravenousToxicityMedicinemedicine.symptomMicrotubule-Associated ProteinsResearch Articlemedicine.drugDrugs and DevicesDrug Research and DevelopmentSubarachnoid hemorrhageCerebrovascular DiseasesScienceNeurosurgeryBrain damageDrug Administration ScheduleModel OrganismsmedicineAnimalsPharmacokineticsLactic Acidcardiovascular diseasesRats WistarBiologyNimodipineDose-Response Relationship Drugbusiness.industryCalcium-Binding ProteinsAngiography Digital SubtractionDigital subtraction angiographySubarachnoid Hemorrhagemedicine.diseaseRatsnervous system diseasesDelayed-Action PreparationsAngiographyRatNimodipineSurgerybusinessPolyglycolic AcidPLoS ONE
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DOSE-RELATED EFFICACY OF A CONTINUOUS INTRACISTERNAL NIMODIPINE TREATMENT ON CEREBRAL VASOSPASM IN THE RAT DOUBLE SUBARACHNOID HEMORRHAGE MODEL

2009

Objective Intracisternal continuous therapy is a concept in the treatment of cerebral vasospasm after subarachnoid hemorrhage. The purpose of the current study was to investigate the effect of intracisternal nimodipine after induced vasospasm. Methods Sixty-five male Wistar rats were randomized into 4 groups: the control sham-operated group, the control subarachnoid hemorrhage-only group, and the treatment groups receiving 5 or 10 microL/hour of intracisternal nimodipine continuously for 5 days via subcutaneously implanted Alzet osmotic pumps (Durect Corp., Cupertino, CA). Vasospasm was analyzed 5 days later by means of digital subtraction angiography. Morphological examination of the brain…

MaleSubarachnoid hemorrhageRandom AllocationCerebral vasospasmmedicineAnimalsVasospasm IntracranialRats WistarNimodipineAntihypertensive AgentsDose-Response Relationship Drugmedicine.diagnostic_testbusiness.industryVasospasmIntracranial ArteryDigital subtraction angiographySubarachnoid Hemorrhagemedicine.diseaseCerebral AngiographyRatsDose–response relationshipAnesthesiaNimodipineSurgeryNeurology (clinical)medicine.symptomDrug ContaminationbusinessVasoconstrictionmedicine.drugNeurosurgery
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Evaluation of a murine single-blood-injection SAH model.

2014

The molecular pathways underlying the pathogenesis after subarachnoid haemorrhage (SAH) are poorly understood and continue to be a matter of debate. A valid murine SAH injection model is not yet available but would be the prerequisite for further transgenic studies assessing the mechanisms following SAH. Using the murine single injection model, we examined the effects of SAH on regional cerebral blood flow (rCBF) in the somatosensory (S1) and cerebellar cortex, neuro-behavioural and morphological integrity and changes in quantitative electrocorticographic and electrocardiographic parameters. Micro CT imaging verified successful blood delivery into the cisterna magna. An acute impairment of …

medicine.medical_specialtyCerebellumPathologySubarachnoid hemorrhagePhysiologyCerebral arteriesNeurophysiologylcsh:MedicineCisterna magnaSomatosensory systemInternal medicinemedicineMedicine and Health Sciencescardiovascular diseaseslcsh:ScienceElectrocorticographyBrain MappingBrain DiseasesCerebral IschemiaMultidisciplinarymedicine.diagnostic_testbusiness.industryNeurotransmissionlcsh:RBiology and Life SciencesElectroencephalographymedicine.diseasenervous system diseasesmedicine.anatomical_structureCerebral blood flowBrain ElectrophysiologyNeurologyCerebellar cortexCardiologylcsh:QbusinessResearch ArticleNeuroscienceNervous System PhysiologyPLoS ONE
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