0000000000464097
AUTHOR
Juan Salvador Nácher Roselló
Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down syndrome correlate with structural plasticity markers
Down syndrome (DS) is the most common chromosomal aneuploidy. Although trisomy on chromosome 21 can display variable phenotypes, there is a common feature among all DS individuals: the presence of intellectual disability. This condition is partially attributed to abnormalities found in the hippocampus of individuals with DS and in the murine model for DS, Ts65Dn. To check if all hippocampal areas were equally affected in 4-5 month adult Ts65Dn mice, we analysed the morphology of dentate gyrus granule cells and cornu ammonis pyramidal neurons using Sholl method on Golgi-Cox impregnated neurons. Structural plasticity has been analysed using immunohistochemistry for plasticity molecules follow…
Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients
Schizophrenia is a severe mental disorder affecting around 1% of the opulation. This disease presents a complex aetiology that has not been completely unveiled yet. Auditory hallucinations are a very significant and disruptive symptom of schizophrenia affecting between 60% and 80% of schizophrenic patients. In this paper we have used a network-based transcriptomic analysis aiming to identify differences in gene expression between schizophrenic patients with and without auditory hallucinations. Gene expression data from blood samples drained from 30 schizophrenia patients were generated using Affymetrix Human Gene 2.0 ST Genechips. Affymetrix Expression console was used for normalization and…
El perill dels neuroproductes
L'article alerta sobre el perill de l'us inadequat i l'abús de substàncies i preparats que afecten el nostre sistema nerviós.
Temes 2, 3 i 4 de Neurobiologia, Grau de Biologia
Neurotrofines, sinaptogènesi, supervivència i mort neuronal. Paper en el desenvolupament, la degeneració i en la neurotoxicitat. El con de creixement axònic. Estructura i funció neuronal. Estructura de la neurona i la sinapsi. La glia: Paper en el desenvolupament del sistema nerviós, la funció neural i la neurodegeneració. La presentació forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València.