Additional file 1: of Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies

PRISMA-P checklist. (DOCX 24 kb)

Association of Anorexia Nervosa With Risk of Cancer: A Systematic Review and Meta-analysis

This systematic review and meta-analysis evaluates the association of anorexia nervosa with the cancer incidence and mortality among study populations with anorexia nervosa compared with the general population or those without anorexia nervosa.

Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping

Introduction Acute brain injury is a challenging public health problem worldwide. Elevated intracranial pressure is a common complication after acute brain injury. Hyperosmolar therapy is one of the main therapeutic strategies for the management of intracranial hypertension. This study protocol outlines an umbrella review of meta-analyses which will investigate the benefits and harms of hyperosmolar therapy routinely used for the management of acute brain injury in the intensive care. Methods and analysis We will search PubMed/MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews. We will include meta-analyses of primary research studies (eg, randomised controlled trials, observat…

Additional file 3: of Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

Definitions of specific cancer-site outcomes. (DOCX 27 kb)

Additional file 2: of Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

Key terms for PubMed/MEDLINE search. (DOCX 22 kb)

Additional file 3: of Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

Definitions of specific cancer-site outcomes (DOCX 26 kb)

Digital health interventions for children with ADHD

Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder characterised by a persistent pattern of symptoms of inappropriate and impaired inattention, hyperactivity, or impulsivity, with difficulties often continuing into adulthood.1 It is estimated to affect 37·1 million children and young people (aged ≤20 years) worldwide.2 Although multiple ADHD treatments are available and widely used (eg, evidence-based behaviour therapy, medications, or a combination of both),3,4 their effectiveness has been questioned because they might not fully address the needs of many children with ADHD. Barriers to evidence-based treatment for ADHD include misconceptions and stigma, time, and…

MOESM2 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 2. Data extraction and normalisation processes.

MOESM3 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 3. Reporting checklist.

Mapping of global scientific research in comorbidity and multimorbidity: A cross-sectional analysis

[Background]: The management of comorbidity and multimorbidity poses major challenges to health services around the world. Analysis of scientific research in comorbidity and multimorbidity is limited in the biomedical literature. This study aimed to map global scientific research in comorbidity and multimorbidity to understand the maturity and growth of the area during the past decades. [Methods and findings]: This was a cross-sectional analysis of the Web of Science. Searches were run from inception until November 8, 2016. We included research articles or reviews with no restrictions by language or publication date. Data abstraction was done by one researcher. A process of standardization …

Additional file 1: of Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

PRISMA-P Checklist. (DOCX 27 kb)

Global collaborative networks on meta-analyses of randomized trials published in high impact factor medical journals: a social network analysis

Abstract Background Research collaboration contributes to the advancement of knowledge by exploiting the results of scientific efforts more efficiently, but the global patterns of collaboration on meta-analysis are unknown. The purpose of this research was to describe and characterize the global collaborative patterns in meta-analyses of randomized trials published in high impact factor medical journals over the past three decades. Methods This was a cross-sectional, social network analysis. We searched PubMed for relevant meta-analyses of randomized trials published up to December 2012. We selected meta-analyses (including at least randomized trials as primary evidence source) published in…

The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systematic review and network meta-analysis of randomized controlled trials

[Background] Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD.

Additional file 2: of Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies

Key terms for PubMed/MEDLINE search. (DOCX 20 kb)

Additional file 1: of The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review

Reporting methods and results of CEA Spain_annex. Table S1. PubMed/MEDLINE search strategy. Table S2. Included studies. Table S3. PRISMA Checklist. Figure S1. Flow diagram for study selection. Figure S2. Growth in published cost-effectiveness analyses. Spain, 1989-2014.

MOESM6 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 6. Exploratory analysis of topical data.

Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis

INTRODUCTION: There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequences, have been promoted as an important tool to inform decision-making. The objective of this study will be to investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness and reproducibility. METHODS AND ANALYSIS: This is the study protocol for a cross-sectional comparative ana…

MOESM5 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 5. List of excluded articles.

MOESM2 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 2. Data extraction and normalisation processes.

Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cultural factors. Cancer is the second leading cause of death worldwide. At present, no systematic reviews and meta-analyses have evaluated the risk of cancer in people with anorexia nervosa. The objective of this study will be to evaluate the association between anorexia nervosa and the risk of developing or dying from cancer. METHODS/DESIGN: This study protocol is part of a syst…

MOESM1 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 1. Full strategy in PubMed/MEDLINE.

MOESM1 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 1. Full strategy in PubMed/MEDLINE.

Additional file 1: of Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

PRISMA-P Checklist (DOCX 27 kb)

Additional file 1: of Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies

PRISMA-P checklist. (DOCX 24 kb)

MOESM4 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 4. List of PMID for included articles.

Additional file 2: of Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

Key terms for PubMed/MEDLINE search. (DOCX 22 kb)

Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies

BACKGROUND: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may have a significant negative impact on the health and longevity of those with the disorder and their relatives. The aim of this study will be to analyze the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. METHODS/DESIGN: We will conduct a systematic review and meta-analysis of observational studies. Searches of PubMed/MEDLINE, EMBASE, PsycINFO, SCOPUS, and ISI Web of Science will be used to identify epidemiologica…

The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review with network meta-analyses of randomised trials.

Background Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed psychiatric disorders in childhood. A wide variety of treatments have been used for the management of ADHD. We aimed to compare the efficacy and safety of pharmacological, psychological and complementary and alternative medicine interventions for the treatment of ADHD in children and adolescents. Methods and findings We performed a systematic review with network meta-analyses. Randomised controlled trials (≥ 3 weeks follow-up) were identified from published and unpublished sources through searches in PubMed and the Cochrane Library (up to April 7, 2016). Interventions of interest were pharmacolo…

Additional file 1: of Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

PRISMA-P Checklist. (DOCX 27 kb)

Additional file 2: of Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

Key terms for PubMed/MEDLINE search (DOCX 22 kb)

MOESM6 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 6. Exploratory analysis of topical data.

Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

[Background] The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer.

The quality of reporting methods and results of cost-effectiveness analyses in Spain: a methodological systematic review

Open Access; Open Peer Review.-- et al.

Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism:A systematic review and meta-analysis

Background: The long-term risk for recurrent venous thromboembolism (VTE) during extended anticoagulation for a first unprovoked VTE is uncertain. Objectives: To determine the incidence of recurrent VTE during extended anticoagulation of up to 5 years in patients with a first unprovoked VTE. Methods: MEDLINE, EMBASE, and the Cochrane CENTRAL were searched to identify randomized trials and prospective cohort studies reporting recurrent VTE among patients with a first unprovoked VTE who were to receive anticoagulation for a minimum of six additional months after completing ≥3 months of initial treatment. Unpublished data on number of recurrent VTE and person-years, obtained from authors of in…

Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

[Background]: Randomised controlled trials (RCTs) provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades.

Additional file 3: of Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies

Definitions of specific cancer-site outcomes. (DOCX 27 kb)

Cardiovascular and Renal Outcomes of Renin–Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: A Systematic Review with Network Meta-Analyses

Background Medications aimed at inhibiting the renin–angiotensin system (RAS) have been used extensively for preventing cardiovascular and renal complications in patients with diabetes, but data that compare their clinical effectiveness are limited. We aimed to compare the effects of classes of RAS blockers on cardiovascular and renal outcomes in adults with diabetes. Methods and Findings Eligible trials were identified by electronic searches in PubMed/MEDLINE and the Cochrane Database of Systematic Reviews (1 January 2004 to 17 July 2014). Interventions of interest were angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and direct renin (DR) inhibitors. T…

Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library

© Author(s) (or their employer(s)) 2019.

Long-term risk for major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta-analysis

BACKGROUND The long-term risk for major bleeding in patients receiving extended (beyond the initial 3 to 6 months) anticoagulant therapy for a first unprovoked venous thromboembolism (VTE) is uncertain. PURPOSE To determine the incidence of major bleeding during extended anticoagulation of up to 5 years among patients with a first unprovoked VTE, overall, and in clinically important subgroups. DATA SOURCES MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to 23 July 2021. STUDY SELECTION Randomized controlled trials (RCTs) and prospective cohort studies reporting major bleeding among patients with a first unprovoked VTE who were to receive oral anticoagu…

Additional file 2: of Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies

Key terms for PubMed/MEDLINE search. (DOCX 20 kb)

MOESM4 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 4. List of PMID for included articles.

MOESM3 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 3. Reporting checklist.

Revisiones rápidas para la síntesis de la evidencia

MOESM5 of Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis

Additional file 5. List of excluded articles.