0000000000465356

AUTHOR

Alan Codoñer-alejos

showing 3 related works from this author

PS-078 Clinical Relevance Of Gamma-glutamyl Transpeptidase In Childhood Obesity

2014

Background and aims Metabolic risk leads to severe comorbidities in obesity. We evaluate the relationship between the values of gamma-glutamyl trans peptidase (GGT), a marker of hepatic involvement, and cardio metabolic risk factors in obese children. Methods A prospective cross-sectional study of 147 children (aged 7 to 16 years) was carried out. Ninety-five children were obese with a body mass index standard deviation score (SDS-BMI) >2 and 52 children were normal weight. Patients with endocrine disease or syndromic obesity were excluded. We have analysed clinical parameters of adiposity (fat mass by bioelectrical impedance, waist and hip circumference), blood pressure, and classical bioc…

medicine.medical_specialtyWaistmedicine.diagnostic_testbusiness.industrymedicine.diseaseObesityChildhood obesitychemistry.chemical_compoundRetinol binding proteinEndocrinologychemistryInternal medicinePediatrics Perinatology and Child HealthMedicineUric acidbusinessLipid profileBody mass indexBioelectrical impedance analysisArchives of Disease in Childhood
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The rs11187533 C>T Variant of the <b><i>FFAR4</i></b> Gene Is Associated with Lower Levels of Fasting Glucose and De…

2020

<b><i>Introduction:</i></b> Genetic factors can modulate the development of associated comorbidities in obesity. It has been shown that loss-of-function variants of the <i>free fatty acid receptor 4 (FFAR4)</i> gene negatively affect obesity comorbidities such as insulin resistance and fatty liver disease. <b><i>Objective:</i></b> To test the relationships of metabolic factors in children with obesity with variants of the <i>FFAR4</i> gene. <b><i>Methods:</i></b> We performed an association study of 3 single nucleotide polymorphisms (SNPs) of <i>FFAR4</i> (rs10882273 T>C, rs1…

0301 basic medicineLiver injurymedicine.medical_specialty030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industryFatty liverMedicine (miscellaneous)030209 endocrinology & metabolismSingle-nucleotide polymorphismmedicine.diseaseObesityMinor allele frequency03 medical and health sciences0302 clinical medicineInsulin resistanceEndocrinologyInternal medicineGenotypemedicineSNPbusinessAnnals of Nutrition and Metabolism
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Association of RBP4 genetic variants with childhood obesity and cardiovascular risk factors

2015

Background Recent data suggest that retinol-binding protein 4 (RBP4) gene variants could be associated with a risk of obesity and its co-morbidities, such as metabolic syndrome, which increases the risk of developing type 2 diabetes mellitus and cardiovascular disease. Objectives The present study examined the potential association of RBP4 single nucleotide polymorphisms (SNPs) with childhood obesity and its metabolic complications. Methods Four RBP4 SNPs, rs3758538 (3944A>C), rs3758539 (4406G>A), rs12265684 (12177G>C) and rs34571439 (14684T>G), were genotyped in a population of 180 Spanish Caucasian children (97 obese and 83 normal-weight children). Association of RBP4 SNPs with obesity, m…

0301 basic medicinemedicine.medical_specialtyeducation.field_of_studybusiness.industryEndocrinology Diabetes and MetabolismPopulation030209 endocrinology & metabolismSingle-nucleotide polymorphismOdds ratiomedicine.diseaseObesityChildhood obesityMinor allele frequency03 medical and health sciences030104 developmental biology0302 clinical medicineEndocrinologyInsulin resistanceInternal medicinePediatrics Perinatology and Child HealthInternal MedicinemedicineMetabolic syndromeeducationbusinessPediatric Diabetes
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