The Vegf Pathway in Patients with Pancreatic Neuroendocrine Tumors: Efficacy of Everolimus by Baseline Marker Level, and Prognostic and Predictive Effect Analyses from Radiant-3

ABSTRACT Background RADIANT-3 was a phase III study investigating the effect of the mammalian target of rapamycin inhibitor everolimus on progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumors (pNET; Yao et al, NEJM, 2011). Everolimus significantly improved PFS compared with placebo (11 vs 4.6 months, P  Methods Baseline plasma levels of VEGF-A, PlGF, sVEGFR1, and sVEGFR2 were determined by ELISA using multiplexed MSD platform. The optimal cutoffs for these markers were explored using the “survival tree analysis” method. Interaction of treatment and baseline marker status ( Results PFS was significantly improved to a similar extent in patients receiving e…

Cognitive deficits in Behçet disease

The rapid atmospheric monitoring system of the Pierre Auger Observatory

The Pierre Auger Observatory is a facility built to detect air showers produced by cosmic rays above 1017 eV. During clear nights with a low illuminated moon fraction, the UV fluorescence light produced by air showers is recorded by optical telescopes at the Observatory. To correct the observations for variations in atmospheric conditions, atmospheric monitoring is performed at regular intervals ranging from several minutes (for cloud identification) to several hours (for aerosol conditions) to several days (for vertical profiles of temperature, pressure, and humidity). In 2009, the monitoring program was upgraded to allow for additional targeted measurements of atmospheric conditions shor…

CCDC 140465: Experimental Crystal Structure Determination

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CCDC 139089: Experimental Crystal Structure Determination

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CCDC 210648: Experimental Crystal Structure Determination

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CCDC 139090: Experimental Crystal Structure Determination

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CCDC 686576: Experimental Crystal Structure Determination

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CCDC 139088: Experimental Crystal Structure Determination

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CCDC 671663: Experimental Crystal Structure Determination

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CCDC 210649: Experimental Crystal Structure Determination

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CCDC 140466: Experimental Crystal Structure Determination

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CCDC 686575: Experimental Crystal Structure Determination

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CCDC 671662: Experimental Crystal Structure Determination

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CCDC 671664: Experimental Crystal Structure Determination

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CCDC 230611: Experimental Crystal Structure Determination

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CCDC 686579: Experimental Crystal Structure Determination

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CCDC 686580: Experimental Crystal Structure Determination

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CCDC 686577: Experimental Crystal Structure Determination

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CCDC 210650: Experimental Crystal Structure Determination

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CCDC 686578: Experimental Crystal Structure Determination

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