0000000000470971

AUTHOR

Christina Backes

showing 3 related works from this author

Erratum to: miRNAs and sports: tracking training status and potentially confounding diagnoses

2016

Erratum to: J Transl Med (2016) 14:219 DOI 10.1186/s12967-016-0974-x Unfortunately, the original version of this article [1] contained an error. The name of the author [Farbod Sedaghat] was incorrect, the author's surname should be Sedaghat-Hamedani. The author's name is Farbod Sedaghat-Hamedani.

Medicine(all)0301 basic medicinePathologymedicine.medical_specialtyBiochemistry Genetics and Molecular Biology(all)business.industryConfoundingGeneral MedicineGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences030104 developmental biology0302 clinical medicine030220 oncology & carcinogenesisFamily medicinemedicineTracking (education)Medical diagnosisbusinessJournal of Translational Medicine
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Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase

2015

Proteomics analysis of paired cancer and control tissue can be applied to investigate pathological processes in tumors. Advancements in data-independent acquisition mass spectrometry allow for highly reproducible quantitative analysis of complex proteomic patterns. Optimized sample preparation workflows enable integrative multi-omics studies from the same tissue specimens. We performed ion mobility enhanced, data-independent acquisition MS to characterize the proteome of 21 lung tumor tissues including adenocarcinoma and squamous cell carcinoma (SCC) as compared to control lung tissues of the same patient each. Transcriptomic data were generated for the same specimens. The quantitative prot…

Proteomics0301 basic medicinePathologymedicine.medical_specialtyLung NeoplasmsProteomeSystems biologyProteomicsTranscriptometranscriptomics03 medical and health sciencesBiomarkers TumormedicineHumansLung cancerNeoplasm Stagingmass spectrometryadenocarcinomabusiness.industryGene Expression Profilingproteomics analysisPrognosismedicine.diseaseGene expression profiling030104 developmental biologyOncologyCase-Control StudiesProteomeCarcinoma Squamous CellAdenocarcinomalung tumorsTranscriptomebusinessQuantitative analysis (chemistry)Follow-Up StudiesResearch PaperOncotarget
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miRNAs and sports: tracking training status and potentially confounding diagnoses.

2016

Background The dependency of miRNA abundance from physiological processes such as exercises remains partially understood. We set out to analyze the effect of physical exercises on miRNA profiles in blood and plasma of endurance and strength athletes in a systematic manner and correlated differentially abundant miRNAs in athletes to disease miRNAs biomarkers towards a better understanding of how physical exercise may confound disease diagnosis by miRNAs. Methods We profiled blood and plasma of 29 athletes before and after exercise. With four samples analyzed for each individual we analyzed 116 full miRNomes. The study set-up enabled paired analyses of individuals. Affected miRNAs were invest…

0301 basic medicineMalemedicine.medical_specialtyConfounding Factors (Epidemiology)610Physical exerciseDiseaseBioinformatics796 Athletic and outdoor sports and gamesGeneral Biochemistry Genetics and Molecular Biology79603 medical and health sciences610 Medical sciences MedicinemedicineCluster AnalysisHumansGene Regulatory NetworksMyocardial infarctionExercise physiologyExerciseMedicine(all)Principal Component AnalysisbiologyAthletesbusiness.industryBiochemistry Genetics and Molecular Biology(all)ResearchGene Expression ProfilingConfoundingConfounding Factors EpidemiologicResistance TrainingGeneral Medicinemedicine.diseasebiology.organism_classificationGene expression profilingMicroRNAs030104 developmental biologyPhysical therapyErratumbusinessSportsJournal of translational medicine
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