0000000000470997

AUTHOR

Teresa Chiacchio

showing 4 related works from this author

Impact of antiretroviral and tuberculosis therapies on CD4 + and CD8 + HIV/M. tuberculosis-specific T-cell in co-infected subjects

2018

Abstract Background Human Immunodeficiency Virus (HIV) infection is a risk factor for tuberculosis (TB). Antiretroviral therapy (ART) changed HIV clinical management but it is still unclear how pre-existing HIV/Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T-cells are restored. Aim to evaluate the impact of ART and TB therapies on the functional and phenotypic profile of Mtb-specific antigen-response of CD4+ and CD8+ T-cells in prospectively enrolled HIV-TB co-infected patients. Methods ART-naive HIV-infected patients, with or without active TB or latent TB infection (LTBI), were enrolled before and after starting ART and TB therapies. Peripheral blood mononuclear cells (PBMC) wer…

AdultMale0301 basic medicineTuberculosisTuberculosiImmunologyT-Lymphocyte SubsetMycobacterium tuberculosiPeripheral blood mononuclear cellMycobacterium tuberculosisAntitubercular Agent03 medical and health sciences0302 clinical medicineAntigenImmunology and AllergyMedicineHIV Infection030212 general & internal medicineCD8 + T-cellsRisk factorCytokineHIV AntigenAntigens BacterialbiologyCoinfectionbusiness.industryHIVvirus diseasesCD8-Positive T-Lymphocytebacterial infections and mycosesmedicine.diseasebiology.organism_classification030104 developmental biologyHIV AntigensCD4-Positive T-LymphocyteCD4 + T-cellsTuberculosis therapyImmunologyLeukocytes MononuclearCoinfectionAnti-Retroviral AgentFemalebusinessARTCD8HumanImmunology Letters
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New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response

2009

Abstract Background Interferon-gamma (IFN-γ) release assays (IGRAs) were designed to detect latent tuberculosis infection (LTBI). However, discrepancies were found between the tuberculin skin test (TST) and IGRAs results that cannot be attributed to prior Bacille Calmètte Guerin vaccinations. The aim of this study was to evaluate tools for improving LTBI diagnosis by analyzing the IFN-γ response to RD1 proteins in prolonged (long-term response) whole blood tests in those subjects resulting negative to assays such as QuantiFERON-TB Gold In tube (QFT-IT). Methods The study population included 106 healthy TST+ individuals with suspected LTBI (recent contact of smear-positive TB and homeless) c…

AdultMalemedicine.medical_specialtyTuberculosisTuberculinlcsh:Infectious and parasitic diseasesMycobacterium tuberculosisInterferon-gammaYoung AdultMedical microbiologyAntigenLatent TuberculosismedicineHumanslcsh:RC109-216tuberculosis latent infection IGRA testAntigens BacterialLatent tuberculosisbiologyTuberculin Testbusiness.industryMycobacterium tuberculosisMiddle Agedmedicine.diseasebiology.organism_classificationbacterial infections and mycosesVaccinationLong term responseInfectious DiseasesImmunologyFemaleReagent Kits DiagnosticbusinessResearch ArticleBMC Infectious Diseases
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Immune characterization of the HBHA-specific response in Mycobacterium tuberculosis-infected patients with or without HIV infection.

2017

Introduction RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active tuberculosis (TB) disease. Conversely, a positive response to heparin-binding haemagglutinin (HBHA)-based IGRAs, among TB-infected subjects, correlates with Mycobacterium tuberculosis (Mtb) containment and low risk of TB progression. The aim of this study was to characterize HBHA-immune responses in HIV-infected and uninfected subjects with active TB or latent TB infection (LTBI). Methods 49 subjects were prospectively enrolled: 22 HIV-uninfected (13 TB, 9 LTBI) and 27 HIV-infected (12 HIV-TB, 15 HIV-LTBI). Whole blood and peripheral blood mononuclear cells were stimulated with HBHA and RD1 anti…

Genetics and Molecular Biology (all)0301 basic medicineBacterial DiseasesRNA virusesCD4-Positive T-LymphocytesMalePhysiologylcsh:MedicineHIV InfectionsCD8-Positive T-LymphocytesPathology and Laboratory MedicineBiochemistryMemory T cellsWhite Blood CellsImmunodeficiency VirusesInterferonAnimal CellsImmune PhysiologyLectinsMedicine and Health SciencesProspective Studieslcsh:ScienceInnate Immune SystemMultidisciplinarybiologyT CellsInterleukinvirus diseasesMiddle AgedFlow Cytometry3. Good healthActinobacteriaInfectious DiseasesMedical MicrobiologyViral PathogensVirusesDisease ProgressionCytokinesFemaleCellular TypesPathogensmedicine.drugResearch ArticleAdultTuberculosisImmune CellsImmunologyCytotoxic T cellsEnzyme-Linked Immunosorbent AssayPeripheral blood mononuclear cellMicrobiologySettore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICAMycobacterium tuberculosis03 medical and health sciencesInterferon-gammaImmune systemAntigenRetrovirusesmedicineTuberculosisHumansMicrobial PathogensAdult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; HIV Infections; Humans; Interferon-gamma; Lectins; Male; Middle Aged; Prospective Studies; Tuberculosis; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)Blood CellsBacteriaLentiviruslcsh:ROrganismsBiology and Life SciencesProteinsHIVCell BiologyMolecular Developmentbiology.organism_classificationmedicine.diseaseTropical DiseasesVirology030104 developmental biologyAgricultural and Biological Sciences (all)Immune SystemImmunologylcsh:QInterferonsCD8Mycobacterium TuberculosisDevelopmental BiologyPLoS ONE
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Mycobacterium tuberculosis Immune Response in Patients With Immune-Mediated Inflammatory Disease

2021

Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have an intrinsic higher probability to develop active-tuberculosis (TB) compared to the general population. The risk ranges from 2.0 to 8.9 in RA patients not receiving therapies. According to the WHO, the RA prevalence varies between 0.3% and 1% and is more common in women and in developed countries. Therefore, the identification and treatment of TB infection (TBI) in this fragile population is important to propose the TB preventive therapy. We aimed to study the M. tuberculosis (Mtb) specific T-cell response to find immune biomarkers of Mtb burden or Mtb clearance in patients with different TB …

TuberculosisImmunologyPopulationchemical and pharmacologic phenomenaDiseaseMycobacterium tuberculosisImmune systemmedicineM. tuberculosisImmunology and AllergyCytotoxic T celleducationIFN-γCD27Original Researcheducation.field_of_studybiologybusiness.industryRC581-607bacterial infections and mycosesmedicine.diseasebiology.organism_classificationtuberculosisRheumatoid arthritisImmunologyTumor necrosis factor alphaImmunologic diseases. Allergybusinessimmune-mediated inflammatory disease
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