0000000000471615
AUTHOR
J. E. Peris
showing 2 related works from this author
Pharmacokinetic interaction between efavirenz and ketoconazole in rats
2009
It is well known that efavirenz and ketoconazole act as an inducer and inhibitor of CYP3A4, respectively. As a result of these actions, co-administration of these drugs may result in changes in the pharmacoki- netic parameters of one or both of them. 2. Duodenum-cannulated rats have been used to compare the effect of intraduodenal (KC i.d. ) and intrave- nous administration of ketoconazole (KC i.v. ) on the pharmacokinetics of efavirenz after intraduodenal administration, as well as the potential effect of efavirenz as a CYP450 inducer on ketoconazole phar - macokinetic profile. 3. While KC i.v. did not show any significant effect on efavirenz pharmacokinetic profile, KC i.d. increased sig-…
Determination of Lobenzarit Disodium in Human Plasma by High-Performance Liquid Chromatography
1998
Abstract A reversed-phase high performance liquid chromatographic procedure was developed for determination of lobenzarit disodium in human plasma over the range 0.5−17.5 μg/mL with diphenylamine as internal standard. Plasma samples were extracted with acetonitrile and an aliquot was injected onto a Lichrospher 100 RP-18 column with ultraviolet absorbance detection at 308 nm. Composition of the mobile phase was acetonitrile-water-glacial acetic acid (50:50:0.2 v/v/v).