0000000000476919
AUTHOR
Guarnotta V.
Hepatic incidentaloma: An asymptomatic ectopic thyroid tissue
An ectopic thyroid is a form of thyroid dysgenesis in which the entire thyroid gland or parts of it may be located in another part of the body than the usual place. The most frequent location is the base of the tongue. Although most cases are asymptomatic, symptoms related to tumor size and its relationship with surrounding tissues, hormonal dysfunction, and seldom malignancy may also occur. Here, we describe the case of an asymptomatic woman who was thyroidectomized 19 years previously for a toxic goiter and treated with conventional L-thyroxine therapy, until we enacted a progressive reduction of dosage of the replacement therapy. Incidentally, because of occasional abdomen discomfort, sh…
Maggiore rischio cardiometabolico in pazienti di razza non caucasica affetti da diabete mellito di tipo 1 idiopatico rispetto alla forma autoimmune in pazienti caucasici.
Introduzione: Il diabete mellito di tipo 1 idiopatico (DM1b) è caratterizzato da un esordio con insulinopenia, chetoacidosi, assenza di marcatori di autoimmunità β-cellulare e HLA-correlati. Scopo dello studio è stato confrontare i parametri metabolici e clinici, le complicanze micro e macroangiopatiche, la disfunzione adiposa viscerale e gli indici di insulino-secrezione e sensibilità nei pazienti con DM1b ed autoimmune (DM1a) all’esordio clinico. Metodi: 25 pazienti non caucasici con DM1b and 25 caucasici con DM1a, appaiati per età e genere, sono stati retrospettivamente inclusi nello studio. Abbiamo valutato BMI, circonferenza vita, assetto lipidico, glicemia, HbA1c, I.R., GOT e GPT, C-p…
Immune checkpoint blockade for Merkel cell carcinoma: actual findings and unanswered questions
Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine carcinoma arising from the skin. We aimed to review and deal with some of the most relevant controversial topics on the correct use of immunotherapy for the treatment of MCC. Methods: The primary search was carried out via PubMed, EMBASE, and the Cochrane Library (until 31st May, 2018), while other articles and guidelines were retrieved from related papers or those referenced in these papers. Additionally, we performed an extensive search on ClinicalTrials.gov to gather information on the ongoing clinical trials related to this specific topic. Results: We performed an up-to-date critical review taking into account the…
Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks
Pheochromocytoma and paraganglioma are neuroendocrine neoplasms, originating in the adrenal medulla and in parasympathetic and sympathetic autonomic nervous system ganglia, respectively. They usually present as localized tumours curable with surgery. However, these tumours may exhibit heterogeneous clinical course, ranging from no/minimal progression to aggressive (progressive/metastatic) behavior. For this setting of patients, current therapies are unsatisfactory. Immune checkpoint inhibitors have shown outstanding results for several types of solid cancers. We therefore aimed to summarize and discuss available data on efficacy and safety of current FDA-approved immune checkpoint inhibitor…