0000000000479202

AUTHOR

M. N. Zeenny

showing 2 related works from this author

THE FINGERPRINT OF THE HUMAN GASTROINTESTINAL TRACT MICROBIOTA: A HYPOTHESIS OF MOLECULAR MAPPING

2017

The precise etiology of Inflammatory Bowel Disease (IDB) remains unclear and several factors are believed to play a role in its development and progression, including the composition of microbial communities resident in the gastrointestinal tract. Human intestinal microbiota are extensive with at least 15,000-36,000 bacterial species. However, thanks to the new development in sequencing and molecular taxonomic methodologies, our understanding of the microbiota population composition, dynamics, and ecology has greatly increased. Intestinal microbiota play a critical role in the maintenance of the host intestinal barrier homeostasis, while dysbiosis, which involves reduction in the microbiome…

Settore MED/12 - Gastroenterologiagastrointestinal tract microbiota dysbiosis Inflammatory Bowel Diseases molecular mapping fingerprintInflammatory Bowel DiseasesDNA FingerprintingAnti-Bacterial AgentsBacterial Typing TechniquesGastrointestinal MicrobiomeGastrointestinal TractSettore MED/18 - Chirurgia GeneraleRNA Ribosomal 16SDNA Barcoding TaxonomicDysbiosisHomeostasisHumansMolecular Targeted TherapyPrecision MedicineOligonucleotide Array Sequence Analysis
researchProduct

Lactobacillus casei and Bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfon…

2014

Probiotics (PB) are living microorganisms that act as a commensal population in normal intestines and confer numerous beneficial effects on the host. The introduction of probiotics in the treatment of inflammatory bowel disease (IBD) prolongs remission. The aim of this study was to investigate the intestinal and hepatic effects of PB supplementation in an experimental IBD model in mice induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). In the first step of the experimental procedure, CD-1 male mice, 5 to 6 weeks old, were randomly divided into 3 groups and inoculated intrarectally with, respectively, saline, alcohol, or TNBS to assess the experimental IBD model. In the second step, mice…

MaleLacticaseibacillus caseiMiceLiverTrinitrobenzenesulfonic AcidProbioticsDietary SupplementsAnimalsHumansBifidobacteriumIntestinal MucosaInflammatory Bowel DiseasesIntestinal Inflammation intestinal cancer microbiotaprobiotic supplementation large bowel liver apoptosis
researchProduct