0000000000480365

AUTHOR

Javier Chaves

showing 3 related works from this author

HPG-HMapper: A DNA hydroxymethylation analysis tool

2019

DNA methylation (mC) and hydroxymethylation (hmC) can significantly affect the normal human development, as well as health and disease status. hmC studies require not only specific treatment of DNA, but also software tools for their analysis. However, there are no software tools capable of analyzing DNA hmC currently. In this article, we propose HPG-HMapper, a parallel software tool for analyzing the DNA hmC data obtained by ten-eleven translocation–assisted bisulfite sequencing. This tool takes as input data the output files of mC aligner tools, and it yields mC maps and the accounting of methylated and hydroxymethylated bases on each chromosome. The design of this tool includes the consi…

DNA Hydroxymethylation0303 health sciencesDisease statusComputer scienceParallel pipelineComputational biologyTheoretical Computer Science03 medical and health scienceschemistry.chemical_compound0302 clinical medicinechemistryHardware and ArchitectureDNA methylationA-DNA030217 neurology & neurosurgerySoftwareDNA030304 developmental biologyThe International Journal of High Performance Computing Applications
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Zinc and smoking habits in the setting of hypertension in a Spanish populations.

2014

The objective of this study was to evaluate the relationship between trace and toxic amounts of zinc (Zn) in biological samples (blood and urine) and the smoking habits of hypertensive patients and healthy control subjects in Valladolid (Spain). In order to compare biological samples, the concentrations of these samples were measured using inductively coupled plasma mass spectrometry. The limits of detection for Zn in blood plasma ranged between 4.22 and 17.34 μmol l(-1) and were <0.08 μmol g(-1) creatinine in urine. The results of this study indicate that the highest mean values of serum Zn were found in non-hypertensive nonsmokers (13.39±4.35 μmol l(-1)), whereas the highest urine Zn valu…

AdultMalemedicine.medical_specialtyPhysiologySmoking habitchemistry.chemical_elementZincUrinechemistry.chemical_compoundYoung AdultInternal medicineHealthy controlBlood plasmaInternal MedicinemedicineHumansCreatininebusiness.industrySmokingMiddle AgedControl subjectsZincEndocrinologychemistrySpainHypertensionFemaleCardiology and Cardiovascular MedicineCotininebusinessHypertension research : official journal of the Japanese Society of Hypertension
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On the Use of Binary Trees for DNA Hydroxymethylation Analysis

2017

DNA methylation (mC) and hydroxymethylation (hmC) can have a significant effect on normal human development, health and disease status. Hydroxymethylation studies require specific treatment of DNA, as well as software tools for their analysis. In this paper, we propose a parallel software tool for analyzing the DNA hydroxymethylation data obtained by TAB-seq. The software is based on the use of binary trees for searching the different occurrences of methylation and hydroxymethylation in DNA samples. The binary trees allow to efficiently store and access the information about the methylation of each methylated/hydroxymethylated cytosines in the samples. Evaluation results shows that the perf…

0301 basic medicineDNA Hydroxymethylation020203 distributed computingBinary treebusiness.industryComputer science02 engineering and technologyMethylationComputational biologySupercomputer03 medical and health scienceschemistry.chemical_compound030104 developmental biologySoftwareParallel softwarechemistryDNA methylation0202 electrical engineering electronic engineering information engineeringheterocyclic compoundsbusinessDNA
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