0000000000485786

AUTHOR

E Espana-gregori

Effect of different antioxidants in experimental alcoholic optic neuropathy

Purpose To establish the possible beneficial effects of three synthetic antioxidants: S-adenosil-L-methionine (SAMe), N-acetyl-L-cysteine (NAC) and Ebselen in optic nerve damage following chronic ethanol feeding in adult rats. Methods Twenty male Sprague-Dawley rats (five groups of four animals each) were fed a liquid, ethanol-containing diet with littermates given isocaloric amounts of ethanol-free diet serving as controls. Antioxidants were administered by dissolving them in the liquid diet at 0.4 mg/ml (SAMe), 0.163 mg/ml (NAC) and 5.33 mg/ml (Ebselen). After 6 weeks, optic nerves were obtained and parameters that are relevant for the modulation of oxidative stress, such as antioxidants …

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Functional and biomechanical changes in keratoconic corneas after implantation of intracorneal ring segments 5 and 6mm in diameter

Purpose To determinate biomechanical and functional changes in human keratoconic corneas after triangular section ring implantation in two designs. Methods Retrospective study of biomechanical properties of 46 patients (60 eyes) with keratoconus undergoing surgery Keraring® intracorneal ring segments divided into two groups according to 5 or 6 mm of diameter. Surgical technique to made the channel was with IntraLase femtosecond laser. UCVA and BSCVA were measured and biomechanical factors provided by the device ORA before surgery and postoperatively one month, 3 months and 6 months. Results After surgery, we obtained a significant increase (p 0.05). At baseline- 6 months, the improvement in…

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