0000000000485902

AUTHOR

István Andó

showing 3 related works from this author

Nimrod, a Putative Phagocytosis Receptor with EGF Repeats in Drosophila Plasmatocytes

2007

SummaryThe hemocytes, the blood cells of Drosophila, participate in the humoral and cellular immune defense reactions against microbes and parasites [1–8]. The plasmatocytes, one class of hemocytes, are phagocytically active and play an important role in immunity and development by removing microorganisms as well as apoptotic cells. On the surface of circulating and sessile plasmatocytes, we have now identified a protein, Nimrod C1 (NimC1), which is involved in the phagocytosis of bacteria. Suppression of NimC1 expression in plasmatocytes inhibited the phagocytosis of Staphylococcus aureus. Conversely, overexpression of NimC1 in S2 cells stimulated the phagocytosis of both S. aureus and Esc…

Staphylococcus aureusHemocytesMICROBIOEGF-like domainPhagocytosisAmino Acid MotifsReceptors Cell SurfaceBiologymedicine.disease_causeGeneral Biochemistry Genetics and Molecular BiologyPhagocytosisEscherichia colimedicineMelanogasterAnimalsDrosophila ProteinsReceptors ImmunologicReceptorEscherichia coliGeneAgricultural and Biological Sciences(all)Biochemistry Genetics and Molecular Biology(all)Schneider 2 cellsbiology.organism_classificationTransmembrane proteinCell biologyDrosophilaCELLBIOGeneral Agricultural and Biological SciencesCurrent Biology
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Definition ofDrosophilahemocyte subsets by cell-type specific antigens

2008

We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. On the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmatocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged in four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte c…

Cell typeHemocytesBlotting WesternBiologyGeneral Biochemistry Genetics and Molecular BiologyFlow cytometryBlood cellMicePhagocytosisAntigenPrecursor cellmedicineAnimalsCompartment (development)AntigensFluorescent Antibody Technique IndirectGeneral Environmental ScienceMice Inbred BALB Cmedicine.diagnostic_testHematopoietic TissueAntibodies MonoclonalLamellocyte differentiationFlow CytometryMolecular biologyCell Compartmentationmedicine.anatomical_structureNeurologyDrosophilaFemaleActa Biologica Hungarica
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A rapid rosetting method for separation of hemocyte sub-populations of Drosophila melanogaster.

2003

Hemocytes, cellular elements of the innate immune system in insects, play a crucial role in the cellular and humoral immune response. Although a significant amount of information has been collected on their differentiation and function, our understanding of hemocyte development is far from complete. Their characterisation is mostly based on morphological criteria. However, molecular markers were recently identified, defining functional subsets by the aid of monoclonal antibodies. Isolated subsets of hemocytes, in sufficient quantity and purity could help to analyse their development in vitro and also to further define their molecular characteristics. Here we describe an antibody-based roset…

ErythrocytesHemocytesRosette Formationmedicine.drug_classImmunologyHemocyteCell SeparationMonoclonal antibodyImmunophenotypingImmune systemPhagocytosismedicineAnimalsFluorescent Antibody Technique IndirectInnate immune systemSheepbiologyAntibodies Monoclonalbiology.organism_classificationMolecular biologyIn vitroCell biologyDrosophila melanogasterbiology.proteinDrosophila melanogasterAntibodyFunction (biology)Developmental BiologyDevelopmental and comparative immunology
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