0000000000486316

AUTHOR

Gerhard A. Mueller

showing 3 related works from this author

Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure

2021

Aims Improving renal function (IRF) is paradoxically associated with worse outcomes in acute heart failure (AHF), but outcomes may differ based on response to decongestion. We explored if the relationship of IRF with mortality in hospitalized AHF patients differs based on successful decongestion.Methods and results We evaluated 760 AHF patients from AKINESIS for the relationship between IRF, change in B-type natriuretic peptide (BNP), and 1-year mortality. IRF was defined as a >= 20% increase in estimated glomerular filtration rate (eGFR) relative to admission. Adequate decongestion was defined as a >= 40% decrease in last measured BNP relative to admission. IRF occurred in 22% of pat…

InotropeMalemedicine.medical_specialtymedicine.drug_classRenal function030204 cardiovascular system & hematologyKidney03 medical and health sciences0302 clinical medicineKidney functionNatriuretic PeptideB&#8208Internal medicineNatriuretic Peptide BrainNatriuretic peptidemedicinetype natriuretic peptideHumansBlood urea nitrogenAgedHeart Failurebusiness.industryAcute heart failure; B-type natriuretic peptide; Congestion; Kidney function; Prognosis; Acute Disease; Aged; Biomarkers; Humans; Kidney; Male; Natriuretic Peptide Brain; Prognosis; Heart FailureHazard ratioBrainAcute heart failuremedicine.diseasePrognosisConfidence interval3. Good healthBlood pressureB-type natriuretic peptideHeart failureAcute DiseaseCardiologyCongestionCardiology and Cardiovascular MedicinebusinessBiomarkersEuropean Journal of Heart Failure
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B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure

2019

Aims In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. Methods and results The Acute Kidney Injury NGAL Evaluation of Symptomatic heart faIlure Study (AKINESIS) was a prospective, international, multicentre study of AHF patients. Severe WRF (sWRF) was a sustained increase of >= 44.2 mu mol/L (0.5 mg/dL) or >= 50% in creatinine, non-severe WRF (nsWRF) was a non-sustained increase of >= 26.5 mu mol/L (0.3 mg/dL) or >= 50% in cr…

InotropeMaleTime Factorsmedicine.medical_treatmentWorsening renal function030204 cardiovascular system & hematologyKidneyKidney Function TestsRISK STRATIFICATIONchemistry.chemical_compound0302 clinical medicineAcute heart failure; B-type natriuretic peptide; Mortality; Worsening renal function; Acute Disease; Acute Kidney Injury; Aged; Biomarkers; Creatinine; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Kidney Function Tests; Male; Natriuretic Peptide Brain; Prognosis; Prospective Studies; Time FactorsNatriuretic Peptide BrainNatriuretic peptideProspective StudiesDISCHARGEAcute kidney injuryBrainAcute Kidney InjuryPrognosis3. Good healthDERIVATIONHOSPITALIZATIONCreatinineAcute DiseaseCardiologyDisease ProgressionFemaleCardiology and Cardiovascular Medicinehormones hormone substitutes and hormone antagonistsGlomerular Filtration RateVENOUS CONGESTIONmedicine.medical_specialtymedicine.drug_classRenal functionPRESSUREVALIDATION03 medical and health sciencesNatriuretic PeptideInternal medicinemedicineHumansRenal replacement therapycardiovascular diseasesAgedMechanical ventilationHeart FailureCreatininebusiness.industryMORTALITYAcute heart failuremedicine.diseasechemistryB-type natriuretic peptideHeart failurebusinessBiomarkersFollow-Up Studies
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Utility of Urine Neutrophil Gelatinase-Associated Lipocalin for Worsening Renal Function during Hospitalization for Acute Heart Failure: Primary Find…

2019

ABSTRACT Background: Worsening renal function (WRF) during acute heart failure (AHF) occurs frequently and has been associated with adverse outcomes, though this association has been questioned. WRF is now evaluated by function and injury. We evaluated whether urine neutrophil gelatinase-associated lipocalin (uNGAL) is superior to creatinine for prediction and prognosis of WRF in patients with AHF. Methods and Results: We performed a multicenter, international, prospective cohort of patients with AHF requiring IV diuretics. The primary outcome was whether uNGAL predicted development of WRF, defined as a sustained increase in creatinine of 0.5 mg/dL or ≥50% above first value or initiation of…

MalePROGNOSISInternationalitymedicine.medical_treatmentUrine030204 cardiovascular system & hematologyKidneyKidney Function TestsGastroenterologyTHERAPYCohort Studieschemistry.chemical_compound0302 clinical medicine030212 general & internal medicineProspective StudiesProspective cohort studyDAMAGERISKAged 80 and overAcute kidney injuryIMPAIRMENTAcute Kidney InjuryMiddle Aged3. Good healthHospitalizationbiomarkerAcute heart failure; biomarker; worsening renal functionFemaleCardiology and Cardiovascular MedicineGlomerular Filtration Ratemedicine.medical_specialtyRenal functionDIAGNOSIS03 medical and health sciencesLipocalin-2Internal medicineSTRATIFICATIONmedicineMANAGEMENTHumansRenal replacement therapyAdverse effectAgedHeart FailureCreatininebusiness.industryMORTALITYAcute heart failuremedicine.diseasechemistryHeart failureworsening renal functionbusinessBiomarkersJournal of cardiac failure
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