Author: Katharina Zamzow

0000000000490580

AUTHOR

Katharina Zamzow

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Evolution of the immune landscape during progression of pancreatic intraductal papillary mucinous neoplasms to invasive cancer

2020

ABSTRACT: Background: Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic cancer, which is characterized by an immunosuppressive microenvironment. Yet, the spatial distribution of the immune infiltrate and how it changes during IPMN progression is just beginning to be understood. Methods: We obtained tissue samples from patients who underwent pancreatic surgery for IPMN, and performed comprehensive immunohistochemical analyses to investigate the clinical significance, composition and spatial organization of the immune microenvironment during progression of IPMNs. Survival analysis of pancreatic cancer patients was stratified by tumour infiltrating immune cel…

Male0301 basic medicineResearch paperendocrine system diseasesT cellPancreatic Intraductal Neoplasmslcsh:MedicineGeneral Biochemistry Genetics and Molecular BiologyMalignant transformation03 medical and health sciences0302 clinical medicineImmune systemStromaT-Lymphocyte SubsetsPancreatic cancerTumor MicroenvironmentPremalignant lesionHumansMedicineNeoplasm InvasivenessAgedTumour microenvironmentlcsh:R5-920Intraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmbusiness.industrylcsh:RCancerPancreatic cancerGeneral MedicineMiddle Agedmedicine.disease030104 developmental biologymedicine.anatomical_structure030220 oncology & carcinogenesisCancer researchTumour immunologyFemalelcsh:Medicine (General)businessCD8EBioMedicine

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