Conversion of carbohydrates into 5-HMF in Deep Eutectic Solvents under mild reaction conditions

Eutectogel: materiali per il risanamento ambientale

Eutectogels: Materials for Environmental Recovery

Gluconic acid for eco-friendly Ionic Liquids: chemical and biological investigations

Ionic liquids (ILs) are employed in several fields thanks to their well-known properties. For a long time, ILs were considered the “green” alternative to conventional organic solvents.1 However, the increasing attention on environmental health led to consider different ILs structures and alternative synthetic pathways. Considering the tunability of IL structures, new synthetic approaches with natural sources as starting materials were taken into account.2 Here, new eco-friendly ILs were synthesised using gluconic acid. The structures carry gluconic moiety on the cation or as the anion (Figure 1). Hence, several OH groups decrease toxicity and shape a high coordinative site. These new organi…

Fluorescent supramolecular hydrogels for biomedical applications

Density Functional Theory study of the TTC> TTT Isomerization of a Photochromic Spyropiran Merocyanine

Supramolecular gels of carbohydrates derived salts able to adsorb and reduce Cr (VI)

Idrogel fluorescenti per applicazioni biomediche

Lo studio di idrogel supramolecolari da utilizzare in ambito biomedico è in continua espansione. Questo è dovuto al fatto che, così come gli idrogel polimerici, mostrano eccellenti proprietà meccaniche, ma possono anche essere sottoposti reversibilmente a rigonfiamento o a transizioni gel-sol in risposta a stimoli esterni (temperatura, pH, enzimi, agenti redox).1Ad esempio, la buona risposta degli idrogel supramolecolari agli stimoli fisiologici, insieme alla loro elevata biodegradabilità e biocompatibilità, ne ha permesso l’utilizzo per la diagnosi tumorale. Solitamente, questi materiali sono facilmente assimilati dalle cellule e hanno la funzione di carrier per le molecole attive nel bioi…

Lipase-catalyzed resolution of anti-substituted 1,3-dioxepan-5-ols

Several anti-6-substituted 1,3-dioxepan-5-ols were kinetically resolved using an immobilized lipase (Amano PS–C II) in toluene in the presence of vinyl acetate at 30 C. This approach provided, in some cases, the alcohol and the acetate in high enantiomeric purity, depending on the nature of the substituent (R = N3, SePh, I, OBn) and the acetal group (unsubstituted or dimethyl). The role of the size of substituents is also discussed. Enantiopure anti-6-substituted 1,3-dioxepan-5-ols are useful building blocks.

Inactivation and polymerization of human neuroserpin

Neuroserpin is an inhibitory enzyme, belonging to the family of serpins and involved in several pathologies, such as ischemia, Alzheimer disease, and FENIB (Familial Encephalopathy with Neuroserpin Inclusion Body). Here, we study the mechanism of neuroserpin inactivation and polymerization by different experimental techniques (static and dynamic light scattering, liquid chromatography, Fourier transform infrared spectroscopy, emission spectroscopy). Our results show that at intermediate temperatures (45-55 °C) neuroserpin forms flexible polymers with a size from a few tens to a few hundreds of nanometers. At high temperatures, above 80 °C, our results reveal a different polymeric form, reac…

Cyclodextrins: Heterocyclic molecules able to perform chiral recognition (part i)

Protein diffusion, stability and activity in crowded media

Hybrid ionogels as potential antioxidant agents

In the present study, the influence of CNTs on the gelling ability of some carboxylate imidazolium gelators in ionic liquid solutions has been investigated.

Ionic liquid-cobalt complexes: a thermochromic interaction

Solute-induced Water Structure: Computer Simulation on a Model System

Abstract Two series of Monte Carlo simulations have been carried out on a system consisting of 125 water molecules, one of which is kept fixed to simulate a water molecule whose mobility is restricted by a solute. The results are checked against similar simulations without restrictions, used as a control, and they show how the blocked molecule helps increase both the structural order and the connectivity of the hydrogen bond network. Cooperativity originating from proton polarizability of H-bonds and/or from many-body terms of interaction potentials cannot be involved since we use a rigid water model and ab initio pair potentials. The present findings are interpreted as indicative of a moti…