0000000000496730
AUTHOR
K. Kato
Complete dipole response in [sup 208]Pb from high-resolution polarized proton scattering at 0°
At the Research Center for Nuclear Physics, Osaka, Japan, the 208Pb(p,p´) reaction was measured at Ep=295 MeV and scattering angles Θlab= 0° - 10°. A high energy resolution of the order of ΔE/E ≈ 8x10^-5 was achieved, corresponding to ΔE=25-30 keV (FWHM). Cross sections were extracted by a multipole decomposition analysis of the angular distributions. Dominant contributions at very forward angles originate from E1 excitation due to Coulomb projectile-target interaction and spin M1 transitions caused by the spin-isospin part of the proton-nucleus interaction. A separation of these contributions was performed with two independent methods, viz. a multipole decomposition of the angular distribu…
TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)
ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…