0000000000497004

AUTHOR

Buschiazzo Ho

showing 3 related works from this author

Inhibition of Trypanosoma cruzi by plant extracts used in Chinese medicine.

2004

In this work, we assessed the effect of extracts obtained from 17 plants used in traditional Chinese medicine. These extracts were tested in vitro with the epimastigote form of Trypanosoma cruzi, clone Bra C(15) C(2), at 27 degrees C in F-29 medium at a concentration of 100 microg/ml in axenic cultures. Allopurinol was used as reference drug. Seven plant extracts showed inhibitory activities lower than 25%. Pueraria lobata, Mahonia beaei, Dictamus dasycarpus, Kochia scoparia, Sophora flavescens and Ligustrum lucidum showed effects with inhibition values between 25% and 60%, whereas Lithospermum erythrorhizon, Saussurea lappa, Melia toosendan and Cinnamomum cassia showed the greatest inhibit…

MalePuerariaTrypanosoma cruziMahoniaPharmacognosyPlant RootsInhibitory Concentration 50Parasitic Sensitivity TestsCassiaDrug DiscoveryAnimalsMedicine Chinese TraditionalRats WistarPharmacologySophora flavescensPlants MedicinalbiologyTraditional medicinePlant StemsPlant ExtractsGeneral Medicinebiology.organism_classificationLithospermum erythrorhizonTrypanocidal AgentsRatsFruitSeedsPlant BarkScopariaRhizomeCinnamomumPhytotherapyFitoterapia
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Effect of the chloroform extract of tanacetum vulgare and one of its active principles, parthenolide, on experimental gastric ulcer in rats

1999

Abstract This study examines the anti-ulcerogenic activity of a chloroform extract of Tanacetum vulgare and purified parthenolide, the major sesquiterpene lactone found in the extract. Gastric ulcers induced by oral administration of absolute ethanol to rats were reduced dose-dependently by oral pretreatment of animals with the chloroform extract (2.5–80 mg kg−1) or parthenolide (5–40 mgkg−1). When administered 30 min before challenge with the alcohol the protection ranged between 34 and 100% for the extract and 27 and 100% for parthenolide. When the products were administered orally 24h before treatment with ethanol, 40 mg kg−1 of the extract and of the lactone reduced the mean ulcer index…

MalePharmaceutical SciencePharmacologySesquiterpene lactoneUlcer indexSeverity of Illness Indexlaw.inventionchemistry.chemical_compoundlawOral administrationGastric mucosamedicineAnimalsParthenolideStomach UlcerSulfhydryl CompoundsRats WistarPharmacologychemistry.chemical_classificationPlants MedicinalChloroformEthanolDose-Response Relationship DrugEthanolPlant Extractsbusiness.industryRatsmedicine.anatomical_structureBiochemistrychemistryGastric MucosaSolventsChloroformPhytotherapybusinessSesquiterpenes
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Inhibition of Trypanosoma cruzi growth by medical plant extracts

2002

This study describes the screening of extracts obtained from 18 plants and two fungi used in the Chinese and Mediterranean traditional medicines on epimastigote forms of Trypanosoma cruzi. The extracts were tested against epimastigote of T. cruzi Bra C15C2 clone in vitro at 27 degrees C and at a concentration of 250 microg/ml in axenic culture. Angelica dahurica, A. pubescens, A. sinensis, Astragalus membranaceus, Coptis chinensis, Haplophyllum hispanicum, Phellodendron amurense, Poria cocos, Ranunculus sceleratus and Scutellaria baicalensis showed significant effects against the parasite with a percentage of growth inhibition between 20 and 100%. C. chinensis and R. sceleratus showed the g…

MaleTrypanosoma cruziPharmacognosyInhibitory Concentration 50chemistry.chemical_compoundDrug DiscoveryLeukocytesAnimalsRanunculus sceleratusMedicine Chinese TraditionalRats WistarTrypanosoma cruziPharmacologyPlants MedicinalDose-Response Relationship DrugbiologyTraditional medicineMediterranean RegionPlant ExtractsAngelica dahuricaFungiGeneral MedicineAstragalus propinquusCoptis chinensisbiology.organism_classificationRatsLogistic ModelschemistryPhellodendron amurenseScutellaria baicalensisMedicine TraditionalGrowth inhibitionFitoterapia
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