0000000000505029
AUTHOR
Laura Vainio
showing 5 related works from this author
Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury
2019
Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily of secreted factors, are potent negative regulators of muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim of this study was to investigate if activin 2B (ACVR2B) receptor ligands contribute to myocardial IR injury. Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) and subjected to myocardial ischemia followed by reperfusion for 6 or 24 h. Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function fo…
Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function
2020
Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of systemic blockade of ACVR2B ligands on cardiac function in experimental MI, and defined its efficacy to revert muscle wasting in ischemic heart failure (HF). Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) to study its effect on post-MI cardiac remodeling and on later HF. Cardiac function was determined with echocardiography, and myocardium analyzed with histological and biochemical methods for hypertrophy and fibrosis. Pharmacological blo…
Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function
2020
Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of systemic blockade of ACVR2B ligands on cardiac function in experimental MI, and defined its efficacy to revert muscle wasting in ischemic heart failure (HF). Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) to study its effect on post-MI cardiac remodeling and on later HF. Cardiac function was determined with echocardiography, and myocardium analyzed with histological and biochemical methods for hypertrophy and fibrosis. Pharmacological blo…
Iän, sukupuolen ja harjoittelun yhteys reaktionopeuteen mies- ja naisveteraaniurheilijoilla
2013
IÄN, SUKUPUOLEN JA HARJOITTELUN YHTEYS REAKTIONOPEUTEEN MIES - JA NAISVETERAANIURHEILIJOILLA Laura Vainio Pro gradu –tutkielma Gerontologia ja kansanterveys Jyväskylän yliopisto, liikuntatieteellinen tiedekunta, terveystieteiden laitos Kevät 2013 43 sivua, 1 liite Yksi ikääntymisen mukana tapahtuva toimintojen heikkeneminen ilmenee ärsykkeisiin reagoimisen ja reaktionopeuden hidastumisena. Mitä enemmän ikääntyvillä ihmisillä on nopeutta, kestävyyttä ja lihasvoimaa, sitä paremmin he suoriutuvat jokapäiväisistä arkiaskareista. Fyysinen aktiivisuus on tärkeä osa ikääntyvän ihmisen elämässä. Harjoittelun on todettu vaikuttavan reaktionopeuteen parantavasti. Tutkimuksen tarkoituksena oli tutkia …
Ion yields in HIGISOL experiments based on JYFLTRAP data and PACE4 simulations : based on JYFLTRAP data and PACE4 simulations
2012
The purpose of this thesis was to calculate ion yields in the neutron-deficient mass region A=78-111 in heavy-ion ion-guide experiments at the Ion Guide Isotope Separator On-Line (IGISOL) facility in the Accelerator Laboratory of the University of Jyväskylä. The biggest challenge was that the experiments were not designed for yield calculations but for precision mass measurements. Therefore, only a small fraction of the available data could be used. The results were compared to theoretical cross sections calculated with PACE4 code. Ion yields agreed roughly with the cross-section calculations: On the one hand, the ions with the highest cross sections were detected. On the other hand, ratios…