0000000000509482
AUTHOR
N. Dimitriou
The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit.
BACKGROUND: Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer outcomes than both laparoscopic completed or planned open surgery. The primary aim of this study was to determine whether laparoscopic conversion was associated with a higher major complication rate than planned open surgery in contemporary, international practice.METHODS: Combined analysis of the European Society of Coloproctology 2017 and 2015 audits. Patients were included if they underwent elective resection of a colonic segment from the caecum to the rectosigmoid jun…
Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery
INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any r…
An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)
Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally. Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients undergoing elective total mesorectal excision (TME) for malignancy between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 2579 included patients, 76.2% (1966/257…
Study of the leptonic decays of the Z0 boson
Measurements are presented of the cross section ratios Rℓ = σℓ(e+e-→ℓ+ℓ -)/σhh(e+e-→hadrons) for ℓ = e, μ and τ using data taken from a scan around the Z0. The results are Re = (5.09±0.32±0.18)%, Rμ = (4.96±0.35±0.17)% and Rτ,=(4.72±0.38± 0.29)% where, for the ratio Re, the t-channel contribution has been subtracted. These results are consistent with the hypothesis of lepton universality and test this hypothesis at the energy scale s ∼ 8300 GeV2. The absolute cross sections σℓ(e+e-→ℓ +ℓ-) have also been measured. From the cross sections the leptonic partial widths Γe = (83.2±3.0±2.4) MeV, (ΓeΓμ) 1/2=(84.6±3.0±2.4) MeV and (ΓeΓτ) 1/2=(82.6±3.3±3.2) MeV have been extracted. Assuming lepton un…